Gene: SV2B
Official Full Name: synaptic vesicle glycoprotein 2Bprovided by HGNC
Gene Summary: This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients. [provided by RefSeq, Sep 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04422 | SV2B Knockout cell line (HeLa) | Human | SV2B | 1:3~1:6 | Negative | Online Inquiry |
SV2B Gene Knockout Cell Lines are advanced biological tools specifically engineered to facilitate the study of the synaptic vesicle protein 2B (SV2B), which plays a critical role in neurotransmitter release and synaptic function. These cell lines are created through CRISPR-Cas9 gene-editing technology, resulting in a precise knockout of the SV2B gene. This innovative approach allows researchers to investigate the physiological consequences of SV2B deficiency and to elucidate its involvement in various neurological disorders.
The primary function of SV2B Gene Knockout Cell Lines is to provide a cellular model system that replicates the loss of SV2B expression, allowing for in-depth analysis of synaptic plasticity, neurotransmitter dynamics, and neuronal communications. By utilizing these knockout lines, scientists can explore how alterations in SV2B affect synaptic activity, which is vital for understanding conditions such as epilepsy, autism, and other neurodevelopmental disorders.
In terms of scientific importance, SV2B Gene Knockout Cell Lines serve as valuable platforms in both basic and translational research. They enable the testing of pharmacological agents aimed at restoring synaptic function and assist in the validation of biomarkers and therapeutic strategies for neurological diseases. Additionally, the insight gained from employing these cell lines can help guide future developments in gene therapy and regenerative medicine.
What sets our SV2B Gene Knockout Cell Lines apart from alternatives is their high specificity and efficiency in generating a reliable model of synaptic deficiency. Unlike traditional knockout techniques, the CRISPR-Cas9 method ensures minimal off-target effects and higher efficiency rates, providing researchers with reproducible data crucial for advancing scientific knowledge.
In summary, the SV2B Gene Knockout Cell Lines are invaluable for researchers and clinicians focused on neuroscience and neurobiology. They offer a novel approach to understanding complex neural mechanisms, fostering the development of targeted therapies. Our company's extensive expertise in genetic engineering and commitment to supplying high-quality biological products ensure that our customers receive robust tools designed to support cutting-edge research and discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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