Gene: STXBP5
Official Full Name: syntaxin binding protein 5provided by HGNC
Gene Summary: Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO26417 | STXBP5 Knockout cell line (HeLa) | Human | STXBP5 | 1:3~1:6 | Negative | Online Inquiry |
KO26418 | STXBP5 Knockout cell line (HCT 116) | Human | STXBP5 | 1:2~1:4 | Negative | Online Inquiry |
KO26419 | STXBP5 Knockout cell line (HEK293) | Human | STXBP5 | 1:3~1:6 | Negative | Online Inquiry |
KO26420 | STXBP5 Knockout cell line (A549) | Human | STXBP5 | 1:3~1:4 | Negative | Online Inquiry |
STXBP5 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to disable the STXBP5 gene, which plays a critical role in neurotransmitter release and synaptic function. This innovative product allows researchers to explore the implications of STXBP5 deficiency on various cellular processes, including exocytosis and neuronal signaling pathways. By using these cell lines, scientists can precisely analyze the phenotype changes, biochemical pathways, and physiological responses that occur in the absence of STXBP5, thereby advancing our understanding of its contribution to neurological disorders.
The underlying mechanism of action involves the targeted inactivation of the STXBP5 gene through techniques such as CRISPR/Cas9 or homologous recombination, resulting in a loss-of-function effect. This creates a controlled environment in which the impact of the gene's absence can be studied extensively, revealing novel insights into its role in cellular communication. This capability is valuable not only for basic research but also for the development of therapeutics aimed at addressing associated pathologies, including various psychiatric and neurodegenerative diseases.
One of the significant advantages of STXBP5 Gene Knockout Cell Lines is the specificity and reproducibility they offer over conventional models. Compared to primary neurons or non-specific cell cultures, these knockout lines provide a more consistent platform, reducing variability in experimental outcomes. Furthermore, they enable researchers to bypass the ethical concerns associated with animal models, supporting compliant and humane research practices.
Incorporating STXBP5 Gene Knockout Cell Lines into research can lead to groundbreaking discoveries that inform drug development and intervention strategies targeted at synaptic dysfunction. The relevance of this product extends to academic institutions, pharmaceutical companies, and clinical research organizations seeking innovative solutions to enhance their research capabilities.
At our company, we pride ourselves on our expertise in the field of genetic engineering and our commitment to providing high-quality biological products that meet stringent scientific standards. Our STXBP5 Gene Knockout Cell Lines are a testament to our dedication to advancing research and providing researchers with essential tools to unveil the complexities of gene function and disease mechanisms.
Please note that all services are for research use only. Not intended for any clinical use.
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