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STX4 Knockout Cell Lines

Gene: STX4

Official Full Name: syntaxin 4provided by HGNC

Gene Summary: Enables sphingomyelin phosphodiesterase activator activity. Involved in several processes, including cornified envelope assembly; positive regulation of immune effector process; and positive regulation of protein localization. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and lamellipodium. Part of SNARE complex. Is active in glutamatergic synapse and postsynapse. Implicated in autosomal recessive nonsyndromic deafness. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02106 STX4 Knockout cell line (HeLa) Human STX4 1:3~1:6 Negative Online Inquiry
KO02107 STX4 Knockout cell line (HCT 116) Human STX4 1:2~1:4 Negative Online Inquiry
KO02108 STX4 Knockout cell line (HEK293) Human STX4 1:3~1:6 Negative Online Inquiry
KO02109 STX4 Knockout cell line (A549) Human STX4 1:3~1:4 Negative Online Inquiry

Background

STX4 Gene Knockout Cell Lines are innovative biological tools designed to facilitate the study of the STX4 gene's role in cellular processes. STX4, or syntaxin 4, is a member of the syntaxin protein family, integral to the regulation of membrane trafficking and exocytosis in various cell types. By employing CRISPR/Cas9 gene editing techniques, these cell lines have been rendered deficient in STX4 expression, enabling researchers to investigate the functional implications of STX4 absence and its impacts on cellular physiology.

The key mechanism of these knockout cell lines involves a targeted disruption of the STX4 gene, effectively preventing the synthesis of the associated protein. This genetic alteration leads to discernible changes in vesicle transport, hormone secretion, and neurotransmitter release, presenting a unique opportunity for elucidating the mechanisms underlying various physiological and pathological conditions, including diabetes, neurological disorders, and cancer.

In scientific and clinical contexts, the STX4 Gene Knockout Cell Lines serve as invaluable models for researchers seeking to explore the genetic and molecular pathways influenced by STX4. The insights gained from studies involving these cell lines can shed light on potential therapeutic targets and strategies for manipulating exocytosis-related diseases.

What sets our STX4 Gene Knockout Cell Lines apart from other available options is their high specificity and proven reliability in various experimental setups. Each cell line undergoes rigorous validation to ensure the completeness of the STX4 knockout, allowing researchers to achieve consistent and reproducible results. Additionally, these cell lines are compatible with a range of techniques including gene expression analyses, functional assays, and drug screening, enhancing their utility across multiple research domains.

Investing in STX4 Gene Knockout Cell Lines means equipping your laboratory with a powerful resource for advancing knowledge in cell biology and disease mechanisms. Our company, backed by extensive expertise in genetic engineering and cell line development, is dedicated to providing high-quality products that meet the rigorous demands of the scientific community, ultimately contributing to groundbreaking discoveries in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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