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STUB1 Knockout Cell Lines

Gene: STUB1

Official Full Name: STIP1 homology and U-box containing protein 1provided by HGNC

Gene Summary: This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00202 STUB1 Knockout cell line (HEK293) Human STUB1 1:3~1:6 Negative Online Inquiry

Background

STUB1 Gene Knockout Cell Lines are genetically engineered cellular models that have been specifically designed to lack the expression of the STUB1 gene, which encodes the STUB1 protein known for its role in protein quality control, neuroprotection, and regulation of various cellular processes. These cell lines serve as invaluable tools for researchers aiming to investigate the physiological and pathological roles of STUB1 in both normal and diseased states.

The key mechanism underlying the utility of STUB1 Knockout Cell Lines lies in their ability to facilitate studies on the consequences of STUB1 deficiency. Researchers can employ these models to elucidate the impact of STUB1 on cellular stress responses, protein homeostasis, and apoptotic pathways. By comparing the knockout lines to wild-type controls, scientists can discern the specific functions of STUB1, thus gaining insights into its contribution to neurodegenerative disorders, cancer, and other diseases where protein misfolding is prevalent.

The scientific importance of these cell lines is underscored by their applications in both basic and translational research. They provide a platform for drug screening, allowing for the identification of therapeutic candidates that may restore STUB1 function or compensate for its loss. In clinical settings, knowledge gleaned from studies using these cell lines can lead to novel biomarkers or targeted therapies for STUB1-related pathologies.

Compared to alternative models, STUB1 Knockout Cell Lines offer a unique selling point through their specificity and relevance to human biology. These cells can closely mimic the complexities of human disease, providing more reliable data compared to other models that do not accurately reflect the absence of this critical protein. Furthermore, extensive validation ensures the consistency and reliability of experimental results, making them a trusted choice for rigorous scientific investigation.

For researchers and clinicians focused on understanding the intricate processes of cellular function, these knockout cell lines represent a valuable asset. Their ability to pave the way for breakthroughs in therapeutic development highlights their significance in the quest for innovative solutions to some of humanity's most pressing health challenges.

Our company, with its expertise in providing high-quality biological products, takes pride in offering these STUB1 Gene Knockout Cell Lines, bolstered by a commitment to supporting cutting-edge research through advanced tools and dedicated customer collaboration.

Please note that all services are for research use only. Not intended for any clinical use.

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