Gene: STRADA
Official Full Name: STE20 related adaptor alphaprovided by HGNC
Gene Summary: The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09131 | STRADA Knockout cell line (HeLa) | Human | STRADA | 1:3~1:6 | Negative | Online Inquiry |
KO09132 | STRADA Knockout cell line (HCT 116) | Human | STRADA | 1:2~1:4 | Negative | Online Inquiry |
KO09133 | STRADA Knockout cell line (HEK293) | Human | STRADA | 1:3~1:6 | Negative | Online Inquiry |
KO09134 | STRADA Knockout cell line (A549) | Human | STRADA | 1:3~1:4 | Negative | Online Inquiry |
STRADA Gene Knockout Cell Lines are advanced biological tools engineered to facilitate the exploration of gene function and the study of genetic disorders through precise gene knockout techniques. Utilizing CRISPR/Cas9 technology, these cell lines allow researchers to create specific gene deletions, thereby enabling the investigation of gene expression patterns and the resultant phenotypic changes in a controlled environment.
The core function of STRADA Gene Knockout Cell Lines lies in their ability to effectively disrupt target genes, which enables researchers to assess the biological pathways implicated in various diseases. Upon introduction of the CRISPR/Cas9 system, a guide RNA is designed to match the specific gene target, allowing for precise double-strand breaks in the DNA. The cell's repair mechanisms then introduce insertions or deletions, leading to gene knockout. This process allows for the elucidation of gene function and cellular responses, making it invaluable for applications in developmental biology, pharmacogenomics, and therapeutic research.
The scientific importance of STRADA Gene Knockout Cell Lines cannot be overstated, as they serve as indispensable models for understanding disease mechanisms and testing novel therapeutics. Their applications span from drug discovery to personalized medicine, allowing researchers and clinicians to investigate genetic variants and their associated pathological effects.
Compared to traditional knockout methods, STRADA Cell Lines offer enhanced specificity and efficiency, significantly reducing off-target effects while maximizing genome editing accuracy. Their ready-to-use format enables rapid experimentation, saving researchers valuable time and resources.
In an era where precision medicine is at the forefront, the value of STRADA Gene Knockout Cell Lines to researchers and clinicians is profound. They not only expedite the research process but also elevate the potential to discover groundbreaking treatments. Our company is committed to empowering scientific discovery, backed by extensive expertise in gene editing technologies and a robust portfolio of high-quality biological products tailored to meet the dynamic needs of the research community.
Please note that all services are for research use only. Not intended for any clinical use.
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