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STEAP2 Knockout Cell Lines

Gene: STEAP2

Official Full Name: STEAP2 metalloreductaseprovided by HGNC

Gene Summary: This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13691 STEAP2 Knockout cell line (HCT 116) Human STEAP2 1:2~1:4 Negative Online Inquiry
KO13692 STEAP2 Knockout cell line (HEK293) Human STEAP2 1:3~1:6 Negative Online Inquiry
KO13693 STEAP2 Knockout cell line (A549) Human STEAP2 1:3~1:4 Negative Online Inquiry

Background

STEAP2 Gene Knockout Cell Lines are genetically engineered cellular models in which the STEAP2 gene has been disrupted through precise genome-editing techniques such as CRISPR/Cas9. This gene is known to play a critical role in various biological processes, including iron metabolism and cancer cell proliferation. The knockout of STEAP2 allows researchers to investigate the gene’s specific functions, its involvement in disease mechanisms, and potential therapeutic targets, thereby enhancing our understanding of both fundamental biology and pathology.

The main function of STEAP2 as an iron transporter implicates it in maintaining cellular iron homeostasis, thus impacting cell growth and tumorigenesis. By utilizing STEAP2 Gene Knockout Cell Lines, scientists can explore the downstream effects of iron dysregulation on cellular metabolism, inflammation, and oncogenic signaling pathways. Additionally, these models are pivotal for testing the efficacy of novel drugs aimed at diseases associated with iron overload, such as certain cancers and metabolic disorders.

In terms of scientific significance, STEAP2 Gene Knockout Cell Lines contribute greatly to translational research. They allow for the assessment of the interplay between iron homeostasis and various biological pathways, offering insights into disease mechanisms that can lead to improved therapeutic interventions in clinical settings.

What sets our STEAP2 Gene Knockout Cell Lines apart from alternatives is their high efficiency of gene editing, which results in well-validated knockout models with characterized phenotypes. We provide comprehensive support and detailed characterization data, enabling researchers to reproducibly study STEAP2's role without the variations often introduced in less rigorously validated cell lines.

For researchers, clinicians, and pharmaceutical developers, our STEAP2 Gene Knockout Cell Lines are invaluable tools for the advancement of mechanistic studies and drug development, particularly in the fields of oncology and metabolic disease. Investing in these cell lines can catalyze significant advancements in understanding iron-related pathology and enhancing therapeutic strategies.

Our company is committed to delivering high-quality biological products that empower discovery and innovation in life sciences. With advanced technological capabilities and a team of experienced scientists, we ensure that our offerings meet the highest standards for accuracy and reliability, ultimately supporting your research goals.

Please note that all services are for research use only. Not intended for any clinical use.

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