Gene: STAM
Official Full Name: signal transducing adaptor moleculeprovided by HGNC
Gene Summary: This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11154 | STAM Knockout cell line (HeLa) | Human | STAM | 1:3~1:6 | Negative | Online Inquiry |
KO11155 | STAM Knockout cell line (HCT 116) | Human | STAM | 1:2~1:4 | Negative | Online Inquiry |
KO11156 | STAM Knockout cell line (HEK293) | Human | STAM | 1:3~1:6 | Negative | Online Inquiry |
KO11157 | STAM Knockout cell line (A549) | Human | STAM | 1:3~1:4 | Negative | Online Inquiry |
STAM Gene Knockout Cell Lines are genetically modified cell lines designed specifically to facilitate the study of gene function through the loss of function of the STAM gene. These cell lines have been engineered using CRISPR/Cas9 technology, which ensures precise and efficient gene editing, enabling researchers to create knockout models that are invaluable for elucidating the role of STAM in various biological processes and diseases.
The key functions of STAM knockouts include their roles in the modulation of signaling pathways and regulation of cellular growth and differentiation. By investigating these cell lines, researchers can gain insights into STAM's involvement in immune response, cell proliferation, and apoptosis. The mechanism by which STAM operates involves interacting with multiple signaling molecules, making its knockout a valuable tool for dissecting complex cellular networks and understanding disease pathogenesis.
The scientific importance of STAM Gene Knockout Cell Lines extends into various fields such as immunology, cancer research, and cellular biology. In clinical settings, these models are critical for identifying potential therapeutic targets and understanding drug mechanisms, thus paving the way for the development of innovative treatment strategies.
One notable advantage of STAM knockout cell lines is their reliability and reproducibility when compared to traditional methods, such as RNA interference, which may produce off-target effects or incomplete knockdown. The CRISPR/Cas9 mediated approach ensures complete loss of the target gene and consistent performance across experiments, thus enabling robust and valid scientific inquiry.
Valuable to researchers and clinicians alike, STAM Gene Knockout Cell Lines empower users to explore fundamental biological questions and advance translational research. By providing a reliable and innovative tool for genetic studies, these cell lines help bridge the gap between laboratory research and clinical application.
Our company specializes in providing high-quality biological products tailored for advanced research needs, establishing ourselves as a leader in the field. With a strong commitment to scientific innovation and customer support, we ensure that researchers have the resources they need to make impactful discoveries in gene function and expression studies.
Please note that all services are for research use only. Not intended for any clinical use.
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