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SSH3 Knockout Cell Lines

Gene: SSH3

Official Full Name: slingshot protein phosphatase 3provided by HGNC

Gene Summary: The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13726 SSH3 Knockout cell line (HeLa) Human SSH3 1:3~1:6 Negative Online Inquiry
KO13727 SSH3 Knockout cell line (HCT 116) Human SSH3 1:2~1:4 Negative Online Inquiry
KO13728 SSH3 Knockout cell line (HEK293) Human SSH3 1:3~1:6 Negative Online Inquiry
KO13729 SSH3 Knockout cell line (A549) Human SSH3 1:3~1:4 Negative Online Inquiry

Background

SSH3 Gene Knockout Cell Lines are genetically engineered cellular models designed to specifically disrupt the expression of the SSH3 gene, which encodes a protein involved in the regulation of the actin cytoskeleton and cellular signaling pathways. These cell lines are created through advanced techniques such as CRISPR/Cas9 gene editing, allowing researchers to study the specific effects of SSH3 absence on cellular behavior, morphology, and signal transduction processes.

The primary function of SSH3 is to act as a regulator of Rho GTPase proteins, which play pivotal roles in cytoskeletal dynamics, cell motility, and other critical cellular processes. By generating SSH3 knockout cell lines, researchers can elucidate the precise mechanisms through which SSH3 influences these cellular pathways and can assess the impact of its loss on cell behavior, migration, and invasiveness, particularly in cancer research.

The scientific importance of SSH3 Gene Knockout Cell Lines lies in their utility for investigating the role of SSH3 in various biological contexts, including cancer metastasis and the immune response. These cell lines serve as a powerful tool for understanding disease mechanisms, validating drug targets, and screening potential therapeutics in both academic and clinical settings.

What sets SSH3 Gene Knockout Cell Lines apart from traditional cell line models is their specificity and accuracy. By eliminating SSH3 expression, these models significantly enhance the reproducibility and validity of experimental outcomes, allowing for clearer interpretations of data compared to using wild-type cells where background expression can confound results.

For researchers and clinicians seeking to explore the functional aspects of the SSH3 gene, these knockout cell lines provide an unparalleled opportunity to advance discoveries in cancer biology and related fields. Our company specializes in the development of tailored genetic tools for researchers, leveraging our expertise in molecular biology and genetics to offer products that not only meet the highest standards of quality but also push the frontiers of scientific investigation.

Please note that all services are for research use only. Not intended for any clinical use.

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