Gene: SS18L1
Official Full Name: SS18L1 subunit of BAF chromatin remodeling complexprovided by HGNC
Gene Summary: This gene encodes a calcium-responsive transactivator which is an essential subunit of a neuron-specific chromatin-remodeling complex. The structure of this gene is similar to that of the SS18 gene. Mutations in this gene are involved in amyotrophic lateral sclerosis (ALS). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28444 | SS18L1 Knockout cell line (HeLa) | Human | SS18L1 | 1:3~1:6 | Negative | Online Inquiry |
KO28445 | SS18L1 Knockout cell line (HCT 116) | Human | SS18L1 | 1:2~1:4 | Negative | Online Inquiry |
KO28446 | SS18L1 Knockout cell line (HEK293) | Human | SS18L1 | 1:3~1:6 | Negative | Online Inquiry |
KO28447 | SS18L1 Knockout cell line (A549) | Human | SS18L1 | 1:3~1:4 | Negative | Online Inquiry |
SS18L1 Gene Knockout Cell Lines are specialized cell lines in which the SS18L1 gene has been systematically disrupted or knocked out using state-of-the-art gene editing technologies. This modification creates a robust model for studying the functional implications of SS18L1 in various biological processes, including tumorigenesis, cell signaling, and differentiation pathways. The knockout of this gene provides researchers with a powerful tool to elucidate its contributions to cellular behavior and pathology, offering insights into potential therapeutic targets for diseases associated with aberrant SS18L1 function.
The key mechanism behind these knockout cell lines involves the use of CRISPR-Cas9 technology, which allows for precise editing of specific genomic regions. By employing this innovative approach, researchers can generate a high-fidelity model lacking SS18L1 expression, facilitating studies that assess the gene's role in oncological research and developmental biology. This targeted deletion enables detailed functional assays, such as cellular proliferation, migration, and apoptosis studies, which are pivotal for understanding disease mechanisms and drug responses.
From a scientific perspective, SS18L1 Gene Knockout Cell Lines are invaluable, especially in research settings investigating sarcomas and other malignancies where SS18L1 has been implicated. Their applications extend into preclinical trials, allowing for the assessment of novel therapeutic strategies aimed at restoring normal cellular function or inducing cell death in cancerous tissues.
One of the unique advantages of these knockout cell lines lies in their high specificity and reproducibility compared to traditional knockdown methods, such as RNA interference which can yield incomplete and transient results. SS18L1 Gene Knockout Cell Lines provide a stable foundation for experimental settings, ensuring consistent results over time.
Target users, including biomedical researchers and oncologists, will find exceptional value in utilizing these cell lines to accelerate discoveries in their fields. By simplifying the process of studying gene function while offering reliable and potent outcomes, these cell lines represent an essential addition to any research toolkit aimed at elucidating the complexities of cancers and developing targeted therapies.
Our company specializes in the production of high-quality gene knockout cell lines, leveraging advanced genomic technologies and extensive expertise in molecular biology. We are dedicated to supporting research initiatives by providing reliable biological models that enhance experimental integrity and drive scientific innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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