Gene: SPTSSA
Official Full Name: serine palmitoyltransferase small subunit Aprovided by HGNC
Gene Summary: Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTA is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13746 | SPTSSA Knockout cell line (HeLa) | Human | SPTSSA | 1:3~1:6 | Negative | Online Inquiry |
KO13747 | SPTSSA Knockout cell line (HCT 116) | Human | SPTSSA | 1:2~1:4 | Negative | Online Inquiry |
KO13748 | SPTSSA Knockout cell line (HEK293) | Human | SPTSSA | 1:3~1:6 | Negative | Online Inquiry |
KO13749 | SPTSSA Knockout cell line (A549) | Human | SPTSSA | 1:3~1:4 | Negative | Online Inquiry |
SPTSSA Gene Knockout Cell Lines are specifically engineered cell models that facilitate the study of the SPTSSA gene, which encodes sphingolipid pathways crucial for cellular function. By employing the CRISPR-Cas9 genome-editing technology, these cell lines allow for precise gene knockout, enabling researchers to investigate the biological roles and pathways influenced by SPTSSA deletions. The mechanism behind these cell lines involves the disruption of the SPTSSA gene, leading to knockdown of its protein product, which ultimately impacts sphingolipid metabolism and signaling pathways involved in various cellular processes.
The scientific importance of SPTSSA Gene Knockout Cell Lines cannot be overstated. They serve as vital tools in elucidating the mechanistic underpinnings of diseases linked to aberrant sphingolipid metabolism, including neurodegenerative disorders and certain cancers. Additionally, these cell lines are invaluable in drug discovery and toxicity testing, as they provide a controlled environment to evaluate the effects of potential therapeutic compounds on sphingolipid-related pathways.
One of the key advantages of SPTSSA Gene Knockout Cell Lines compared to other genetic models is their ease of use and reproducibility. With guaranteed and consistent gene disruption, researchers can confidently replicate experiments, yielding reliable data that is pivotal for advancing scientific knowledge. Furthermore, the specificity of the CRISPR-Cas9 technology minimizes off-target effects, further enhancing the accuracy of results.
Researchers and clinicians can derive significant value from the application of these knockout cell lines. They not only facilitate a deeper understanding of sphingolipid physiology but also provide a platform for high-throughput screening of novel therapeutics aimed at modulating sphingolipid pathways. Leveraging our expertise in genetic engineering and cell line production, our company offers meticulously characterized SPTSSA Gene Knockout Cell Lines, enabling scientists to achieve their research goals with efficiency and confidence.
Please note that all services are for research use only. Not intended for any clinical use.
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