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SPRY4 Knockout Cell Lines

Gene: SPRY4

Official Full Name: sprouty RTK signaling antagonist 4provided by HGNC

Gene Summary: This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25648 SPRY4 Knockout cell line (HCT 116) Human SPRY4 1:2~1:4 Negative Online Inquiry
KO25649 SPRY4 Knockout cell line (A549) Human SPRY4 1:3~1:4 Negative Online Inquiry

Background

SPRY4 Gene Knockout Cell Lines represent a sophisticated tool in genetic research, designed primarily for the ablation of the SPRY4 gene, which plays a critical role in cellular signaling pathways, particularly those affecting cell growth and differentiation. By utilizing CRISPR/Cas9 technology for gene editing, these cell lines facilitate the precise knockout of SPRY4, providing researchers with the ability to investigate its function and implications in various biological contexts.

The key functionality of SPRY4 Gene Knockout Cell Lines is rooted in their ability to disrupt SPRY4 gene expression, allowing for the examination of its involvement in key cellular processes, such as the regulation of receptor tyrosine kinases and their downstream signaling cascades. This disruption enables studies on how the absence of SPRY4 influences cellular responses to growth factors and its potential role in oncogenesis, making these cell lines invaluable for cancer research and therapeutic development.

In the realm of scientific research and clinical applications, these cell lines provide significant insights into the genetic underpinnings of diseases. They are particularly useful in translational studies targeting malignancies where SPRY4 is implicated, offering a platform for drug discovery and functional genomics. Compared to other gene knockout models, SPRY4 Gene Knockout Cell Lines offer a robust and reliable approach, with validated high efficiency and specificity in the removal of the target gene.

The unique selling points of this product include its ready-to-use format, comprehensive technical support, and the reproducibility of results, which enhance experimental efficiency and reliability. Researchers and clinicians benefit from the ability to obtain consistent data pivotal for advancing their understanding of SPRY4’s biological impact, further driving innovation in therapeutic strategies.

Our company specializes in providing high-quality biological products, leveraging cutting-edge gene editing technologies and extensive expertise in cell line development. With a commitment to supporting scientific discovery, we equip researchers and clinicians with the tools necessary to explore the complexities of genetic regulation and its implications for human health.

Please note that all services are for research use only. Not intended for any clinical use.

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