Gene: SPPL3
Official Full Name: signal peptide peptidase like 3provided by HGNC
Gene Summary: Enables aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in T cell receptor signaling pathway; membrane protein proteolysis; and positive regulation of calcineurin-NFAT signaling cascade. Located in Golgi-associated vesicle membrane; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29004 | SPPL3 Knockout cell line (HeLa) | Human | SPPL3 | 1:3~1:6 | Negative | Online Inquiry |
KO29005 | SPPL3 Knockout cell line (HCT 116) | Human | SPPL3 | 1:2~1:4 | Negative | Online Inquiry |
KO29006 | SPPL3 Knockout cell line (HEK293) | Human | SPPL3 | 1:3~1:6 | Negative | Online Inquiry |
KO29007 | SPPL3 Knockout cell line (A549) | Human | SPPL3 | 1:3~1:4 | Negative | Online Inquiry |
SPPL3 Gene Knockout Cell Lines are engineered cell models characterized by the targeted disruption of the SPPL3 gene, which encodes for a serine protease involved in cellular signaling pathways. By employing advanced CRISPR/Cas9 gene-editing technologies, these cell lines provide an invaluable tool for studying the biological functions of SPPL3 and its role in various cellular processes, including apoptosis, immune response, and lipid metabolism.
The key mechanism of action of SPPL3 involves its function in regulating the activity of specific substrates through proteolytic cleavage, impacting pathways associated with inflammation and cellular stress responses. The knockout of SPPL3 allows researchers to investigate the phenotypic consequences of its absence, offering insights into the gene's involvement in disease states, particularly in cancer and autoimmune disorders. These experimental models are crucial for elucidating the molecular mechanisms that underpin various pathologies, making the findings applicable to both basic and translational research.
Scientifically, SPPL3 Gene Knockout Cell Lines are of high importance in research settings as they provide a consistent and reliable platform for drug discovery, allowing for the validation of therapeutic targets and the screening of potential inhibitors. Compared to conventional methods, these knockout cell lines offer specificity and reproducibility, thereby enhancing the robustness of experimental results.
The unique selling points of SPPL3 Gene Knockout Cell Lines include their ease of use, customizable applications, and the ability to generate data that can directly inform clinical relevance. Researchers benefit from the availability of a pre-established model that accelerates their investigation timelines and improves data quality.
With a strong commitment to advancing biological research, our company offers a range of expertly validated genetic tools, including the SPPL3 Gene Knockout Cell Lines, designed to meet the highest standards of scientific integrity and applicability in the ever-evolving landscape of cellular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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