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SPON1 Knockout Cell Lines

Gene: SPON1

Official Full Name: spondin 1provided by HGNC

Gene Summary: Predicted to enable LBD domain binding activity and metal ion binding activity. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in cell adhesion. Predicted to act upstream of or within negative regulation of amyloid-beta formation; positive regulation of amyloid precursor protein catabolic process; and positive regulation of protein processing. Located in collagen-containing extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31898 SPON1 Knockout cell line (HEK293) Human SPON1 1:3~1:6 Negative Online Inquiry

Background

SPON1 Gene Knockout Cell Lines are expertly engineered cellular models designed to eliminate the expression of the SPON1 gene, a gene implicated in various biological processes including cellular adhesion, development, and immune responses. The SPON1 protein is known to play a role in the regulation of neuronal function and tissue repair, making these knockout cell lines invaluable for studying gene function and pathway analysis.

The primary mechanism involves the targeted disruption of the SPON1 gene through advanced genetic engineering techniques, such as CRISPR-Cas9, leading to the generation of cell lines that lack functional SPON1 expression. This knockout model allows researchers to elucidate the downstream effects of SPON1 elimination on cellular behavior, signaling pathways, and interactions with the extracellular matrix. Employing these cell lines can significantly broaden understanding of pathological conditions associated with altered SPON1 activity, including neurodegenerative diseases and cancer.

The scientific importance of SPON1 Gene Knockout Cell Lines extends widely in both basic and applied research. In clinical settings, they can serve as potential tools for drug discovery, therapeutic target validation, and understanding disease mechanisms at the cellular level. Compared to traditional cell lines with intact SPON1 expression, knockout models provide a clear, unobstructed view into the gene's function, enhancing the specificity and accuracy of experimental outcomes.

Researchers and clinicians favor SPON1 Gene Knockout Cell Lines due to their precise genetic modifications, which empower scientists to conduct sophisticated experiments with greater reproducibility and reduced variability. Additionally, the availability of these models supports a broad range of applications, from high-throughput screening for small molecules to in-depth studies of signal transduction pathways.

With a commitment to excellence in biological research tools, our company is dedicated to supplying innovative and reliable cell line models, reflecting our expertise in genetic manipulation and cellular biology. By utilizing our SPON1 Gene Knockout Cell Lines, users can ensure their research is built on a foundation of precision and scientific rigor, unlocking new possibilities in the exploration of gene function and therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

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