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SPICE1 Knockout Cell Lines

Gene: SPICE1

Official Full Name: spindle and centriole associated protein 1provided by HGNC

Gene Summary: Involved in metaphase chromosome alignment; mitotic spindle assembly; and regulation of centriole replication. Located in centriole; centrosome; and spindle. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21846 SPICE1 Knockout cell line (HeLa) Human SPICE1 1:3~1:6 Negative Online Inquiry
KO21847 SPICE1 Knockout cell line (HCT 116) Human SPICE1 1:2~1:4 Negative Online Inquiry
KO21848 SPICE1 Knockout cell line (HEK293) Human SPICE1 1:3~1:6 Negative Online Inquiry
KO21849 SPICE1 Knockout cell line (A549) Human SPICE1 1:3~1:4 Negative Online Inquiry

Background

SPICE1 Gene Knockout Cell Lines are genetically engineered cellular models designed to specifically eliminate the expression of the SPICE1 gene, which is involved in various cellular processes including signal transduction and immune response modulation. These knockout cell lines enable researchers to study the functional role of the SPICE1 gene by providing a controlled environment where its absence illuminates its involvement in different biological pathways.

The primary mechanism of action involves the application of CRISPR/Cas9 technology, which allows for precise editing of the genome, resulting in the targeted knockout of the SPICE1 gene. This enables scientists to analyze downstream effects on cell function, gene expression, and phenotypic variations in response to environmental stimuli. The utilization of SPICE1 knockout cell lines is crucial in elucidating the gene's role in pathophysiological conditions, contributing to the understanding of diseases such as cancer and autoimmune disorders.

Scientific studies employing SPICE1 gene knockout cell lines hold significant importance in both research and clinical settings. They serve as vital tools for drug discovery, allowing for the high-throughput screening of potential therapeutics that modulate SPICE1-related pathways. Furthermore, these models can facilitate the identification of biomarkers for disease progression, ultimately aiding in the development of targeted therapies.

Compared to traditional models, such as wild-type cell lines or overexpression systems, SPICE1 gene knockout cell lines provide a more accurate representation of the physiological consequences of SPICE1 deficiency. This specificity leads to more reliable data, enabling researchers to make informed conclusions that can be directly translated into clinical implications.

In summary, SPICE1 Gene Knockout Cell Lines represent an indispensable asset for researchers and clinicians seeking to unravel the complexities of cellular signaling and gene function. By investing in this innovative product, users can leverage our extensive expertise in genetic engineering and cell line development, ensuring they remain at the forefront of scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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