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SOX4 Knockout Cell Lines

Gene: SOX4

Official Full Name: SRY-box transcription factor 4provided by HGNC

Gene Summary: This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09346 SOX4 Knockout cell line (HeLa) Human SOX4 1:3~1:6 Negative Online Inquiry
KO09347 SOX4 Knockout cell line (HCT 116) Human SOX4 1:2~1:4 Negative Online Inquiry
KO09348 SOX4 Knockout cell line (HEK293) Human SOX4 1:3~1:6 Negative Online Inquiry
KO09349 SOX4 Knockout cell line (A549) Human SOX4 1:3~1:4 Negative Online Inquiry

Background

SOX4 Gene Knockout Cell Lines are specially engineered cellular systems that have had the SOX4 gene functionally inactivated, providing a vital tool for the exploration of various biological pathways and disease mechanisms. SOX4, a member of the SOX (SRY-related HMG-box) family of transcription factors, plays a significant role in embryonic development, cell differentiation, and the regulation of pluripotency. By utilizing these knockout cell lines, researchers can evaluate the consequences of SOX4 loss on cellular processes such as proliferation, apoptosis, and lineage specification.

The mechanisms behind the SOX4 gene knockout involve advanced CRISPR-Cas9 technology that precisely disrupts the SOX4 locus, leading to a frame-shift mutation and subsequent loss of gene expression. This enables scientists to observe the phenotypic consequences of SOX4 absence in vitro, facilitating insights into its role in cancer progression, immune response, and other critical areas of research.

From a scientific perspective, these cell lines hold significant importance in elucidating the underlying mechanisms of diseases where SOX4 is implicated, such as various cancers and developmental disorders. They can be employed robustly in both basic research and applied biomedical studies, including drug screening and therapeutic target validation.

One of the standout advantages of our SOX4 Gene Knockout Cell Lines is their consistency and reproducibility, which are crucial for high-quality research. Unlike traditional methodologies that may have variable outcomes, our precisely engineered cell lines allow for controlled experimental setups, thus improving the reliability of data and potential translational applications. Additionally, the ease of use in standard laboratory protocols makes these lines accessible for a wide range of research endeavors.

By providing these high-quality gene knockout cell lines, we empower researchers and clinicians to gain deeper insights into gene function and associated pathological conditions. Our extensive expertise in genetic engineering and commitment to quality ensure that our products meet the rigorous demands of modern biological research. Choose our SOX4 Gene Knockout Cell Lines to accelerate your discoveries and contribute to advancements in health and disease understanding.

Please note that all services are for research use only. Not intended for any clinical use.

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