Gene: SOX2
Official Full Name: SRY-box transcription factor 2provided by HGNC
Gene Summary: This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01028 | SOX2 Knockout cell line (HEK293) | Human | SOX2 | 1:3~1:6 | Negative | Online Inquiry |
KO09855 | SOX2 Knockout cell line (A549) | Human | SOX2 | 1:3~1:4 | Negative | Online Inquiry |
SOX2 Gene Knockout Cell Lines are genetically engineered cell models designed to facilitate the study of the SOX2 gene's function and its role in cellular processes. SOX2 is pivotal in maintaining the pluripotency and self-renewal of embryonic stem cells and is implicated in various developmental and pathological conditions, including cancer. These knockout cell lines have been meticulously developed using CRISPR-Cas9 genome editing technology to precisely disrupt the SOX2 gene, enabling researchers to directly observe the consequences of its absence on cellular behavior, differentiation potential, and signaling pathways.
The primary mechanism by which SOX2 knockout cell lines operate is through the targeted loss of SOX2 expression, leading to alterations in gene regulatory networks associated with cell fate determination. By utilizing these cell lines, researchers can investigate not only the fundamental biological role of SOX2 but also its implications in disease models, providing insights into therapeutic interventions in regenerative medicine and oncology.
The scientific significance of these cell lines extends to their applications in research environments, including drug discovery, gene therapy evaluation, and developmental biology studies. The specific advantages of our SOX2 Gene Knockout Cell Lines include high efficiency in gene editing, robust and consistent physiological response mimicking in vivo environments, and compatibility with various culture conditions and assays.
Unlike other alternatives, our cell lines have been validated through rigorous characterization methods, ensuring reproducibility and accuracy in research outcomes. For researchers and clinicians, these cell lines represent a powerful tool, facilitating innovations in stem cell research, tissue regeneration, and cancer therapy development.
Our company specializes in the production of advanced biological products, leveraging cutting-edge technologies and extensive expertise in genetic engineering, ensuring that researchers have access to high-quality tools that accelerate scientific discovery and translational research.
Please note that all services are for research use only. Not intended for any clinical use.
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