Gene: SORCS1
Official Full Name: sortilin related VPS10 domain containing receptor 1provided by HGNC
Gene Summary: This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30723 | SORCS1 Knockout cell line (HEK293) | Human | SORCS1 | 1:3~1:6 | Negative | Online Inquiry |
SORCS1 Gene Knockout Cell Lines are genetically modified cellular models that have had the SORCS1 gene specifically inactivated or "knocked out," facilitating focused studies on the gene's biological roles and implications. SORCS1, or Sortilin-related VPS10-domain-containing receptor 1, is implicated in various neurological processes, including synaptic transmission and neurodevelopmental disorders. By utilizing these knockout cell lines, researchers can delve into the functional consequences of the absence of SORCS1, thereby gaining insight into its involvement in crucial cellular mechanisms.
The key function of SORCS1 is linked to neurotrophic signaling pathways and molecular transport processes within neurons. The knockout cell lines provide a powerful tool for elucidating these pathways, allowing researchers to observe phenotypic changes that occur in the absence of the gene. Cell viability, neurogenesis, and synaptic plasticity can be rigorously assessed, contributing to the understanding of pathophysiological conditions such as Alzheimer's disease and other cognitive disorders.
In a research setting, SORCS1 Gene Knockout Cell Lines are invaluable for the development of disease models and drug discovery work. Their applications extend to validating therapeutic targets and investigating the mechanisms behind neurological behaviors, ultimately aiding in the creation of targeted interventions. The unique functionality of these cell lines stands out compared to traditional wild-type cell cultures or alternative knockout models, as they provide a highly relevant environment that mimics physiological conditions more accurately.
By employing these specialized cell lines, researchers can save time and resources, significantly enhancing the quality of exploratory studies. The controlled setting in which these cell lines operate allows for reproducibility and precision, aspects that are crucial for any successful research endeavor.
Our company is committed to advancing the field of molecular biology and genetics, with a focus on providing high-quality biological tools that support groundbreaking discoveries. With our expertise and dedication to innovation, we are proud to offer SORCS1 Gene Knockout Cell Lines, empowering researchers and clinicians to unlock the potential of cell-based research to improve human health.
Please note that all services are for research use only. Not intended for any clinical use.
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