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SORBS1 Knockout Cell Lines

Gene: SORBS1

Official Full Name: sorbin and SH3 domain containing 1provided by HGNC

Gene Summary: This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31712 SORBS1 Knockout cell line (HCT 116) Human SORBS1 1:2~1:4 Negative Online Inquiry
KO31713 SORBS1 Knockout cell line (HEK293) Human SORBS1 1:3~1:6 Negative Online Inquiry

Background

SORBS1 Gene Knockout Cell Lines are specifically engineered cellular models that lack the Sorbin and SH3 Domain Containing 1 (SORBS1) gene, a key regulator in various cellular processes including insulin signaling, cell adhesion, and glucose metabolism. These knockout cell lines enable researchers to accurately study the functional implications of SORBS1 absence, contributing to a deeper understanding of metabolic disorders, cardiovascular diseases, and obesity-related pathologies.

The primary mechanism by which SORBS1 influences cellular behavior is through its role in the mediation of insulin receptor signaling pathways, which are crucial for glucose uptake in tissues. By utilizing SORBS1 knockout cell lines, scientists can investigate downstream effects of altered signaling cascades, thereby elucidating potential therapeutic targets for metabolic dysfunction. The absence of SORBS1 simulates a disease model, allowing for the exploration of compensatory mechanisms and the identification of biomarkers associated with insulin resistance and metabolic syndrome.

These cell lines hold tremendous scientific significance in both research and clinical settings, providing a robust platform for drug discovery, functional genomics, and translational studies. They serve as valuable tools for assessing the impact of potential pharmaceuticals aimed at metabolic regulation, thereby facilitating the design of targeted therapies for diseases exacerbated by SORBS1 dysfunction.

In comparison to traditional wild-type cell lines, the SORBS1 knockout cell lines offer unique advantages, such as enhanced specificity in experimental assays, reduced variability in results, and a more refined analysis of gene function. This allows for greater reproducibility and reliability in data collection, essential for advancing scientific knowledge.

Target users, including researchers and clinicians in fields such as endocrinology, metabolism, and cardiovascular science, will find these cell lines indispensable for pioneering studies aimed at understanding complex disease mechanisms. Their capability to streamline research while providing new insights makes them a valuable asset in the quest for improving patient outcomes.

Our company prides itself on its expertise in developing high-quality biological products tailored for cutting-edge research. With a commitment to scientific innovation and customer support, we strive to empower the scientific community to achieve groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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