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SOD1 Knockout Cell Lines

Gene: SOD1

Official Full Name: superoxide dismutase 1provided by HGNC

Gene Summary: The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2020]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00020 SOD1 Knockout cell line (A549) Human SOD1 1:3~1:4 Negative Online Inquiry

Background

SOD1 Gene Knockout Cell Lines are genetically engineered cellular models that have had the superoxide dismutase 1 (SOD1) gene inactivated, providing researchers with essential tools to study the role of this gene in oxidative stress and neurodegeneration. SOD1 is a critical enzyme responsible for catalyzing the dismutation of superoxide radicals into oxygen and hydrogen peroxide, thereby mitigating cellular damage caused by oxidative stress. By utilizing these knockout cell lines, researchers can elucidate the specific pathways and mechanisms by which SOD1 dysfunction contributes to various diseases, particularly amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders.

The key function of SOD1 Gene Knockout Cell Lines lies in their ability to mimic the pathological features observed in disease states, such as disrupted redox balance and increased susceptibility to oxidative damage. This allows for the in-depth investigation of therapeutic strategies aimed at restoring cellular homeostasis and discovering novel targets for intervention. The generated models facilitate high-throughput screening of compounds that could modulate cellular responses to oxidative stress, presenting valuable insights into potential drug candidates.

From a scientific perspective, these knockout cell lines are indispensable in both research and clinical settings. Their ability to replicate disease-relevant phenotypes makes them ideal for experimental setups designed to test hypotheses regarding the etiology of neurodegenerative diseases and their response to therapeutic interventions. Furthermore, they are crucial in studying gene function, developing gene therapies, and investigating signal transduction pathways involved in neural degeneration.

What sets our SOD1 Gene Knockout Cell Lines apart from alternatives is the meticulous validation process they undergo, ensuring reproducibility and reliability in experimental outcomes. Additionally, they come with detailed user guides and support, enabling researchers to maximize their utility in a variety of experimental designs.

Researchers, clinicians, and pharmaceutical developers will find these cell lines particularly valuable for their potential to accelerate the development of innovative treatments, ultimately contributing to better understanding and management of neurodegenerative diseases.

Our company specializes in providing high-quality biological products, bolstered by a team of experts who understand the complexities of genetic engineering and its applications in scientific research. By choosing our SOD1 Gene Knockout Cell Lines, you are ensuring access to advanced tools that will enhance the depth and breadth of your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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