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SNX19 Knockout Cell Lines

Gene: SNX19

Official Full Name: sorting nexin 19provided by HGNC

Gene Summary: Islet antigen-2 (IA-2) is an autoantigen in type 1 diabetes and plays a role in insulin secretion. IA-2 is found in dense-core secretory vesicles and interacts with the product of this gene, a sorting nexin. In mouse pancreatic beta-cells, the encoded protein influenced insulin secretion by stabilizing the number of dense-core secretory vesicles. [provided by RefSeq, Dec 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05618 SNX19 Knockout cell line (HeLa) Human SNX19 1:3~1:6 Negative Online Inquiry
KO05619 SNX19 Knockout cell line (HCT 116) Human SNX19 1:2~1:4 Negative Online Inquiry
KO05620 SNX19 Knockout cell line (HEK293) Human SNX19 1:3~1:6 Negative Online Inquiry
KO05621 SNX19 Knockout cell line (A549) Human SNX19 1:3~1:4 Negative Online Inquiry

Background

SNX19 Gene Knockout Cell Lines represent a significant advancement in cellular research, specifically tailored for the study of the Sorting Nexin protein family and their roles in endosomal trafficking and cellular signaling. These engineered cell lines have been meticulously developed to lack the SNX19 gene, providing researchers with a valuable model to investigate the downstream effects of SNX19 deficiency on cellular processes.

Key functions of the SNX19 Gene Knockout Cell Lines hinge on their ability to elucidate the mechanisms governing endosomal pathways and protein sorting. By comparing the knockout cells to their wild-type counterparts, scientists can discern how the absence of SNX19 alters intracellular trafficking and influences cellular homeostasis. This is particularly relevant in exploring the pathophysiology of various diseases, where aberrant protein sorting is implicated.

From a scientific standpoint, these cell lines are essential for advancing our understanding of genetic regulation, as well as protein interaction networks within cells. Their applications extend to both basic research and translational studies, where they can aid in drug discovery and the development of therapeutic strategies targeting SNX19-related pathways.

Compared to traditional cell models, SNX19 Gene Knockout Cell Lines offer unique advantages, including specificity in gene targeting and robust experimental reproducibility. They provide a more accurate representation of SNX19's biological function without the confounding effects of alternative pathway compensations often observed in less precise models. This specificity equips researchers with tools necessary for detailed mechanistic studies.

For researchers and clinicians, the value of SNX19 Gene Knockout Cell Lines lies in their ability to accelerate discovery and deepen insights into the molecular underpinnings of diseases related to protein trafficking disorders. Utilizing these cell lines can notably enhance the validity of findings and support the development of targeted interventions.

Our company, with its extensive expertise in creating high-quality gene knockout models, is committed to supporting the scientific community with reliable tools that facilitate groundbreaking research and innovations in biomedicine. We believe that our SNX19 Gene Knockout Cell Lines will empower researchers to unlock new levels of understanding in cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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