Home / SMURF1 Knockout Cell Lines

SMURF1 Knockout Cell Lines

Gene: SMURF1

Official Full Name: SMAD specific E3 ubiquitin protein ligase 1provided by HGNC

Gene Summary: This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11465 SMURF1 Knockout cell line (HeLa) Human SMURF1 1:3~1:6 Negative Online Inquiry
KO11466 SMURF1 Knockout cell line (HCT 116) Human SMURF1 1:2~1:4 Negative Online Inquiry
KO11467 SMURF1 Knockout cell line (HEK293) Human SMURF1 1:3~1:6 Negative Online Inquiry
KO11468 SMURF1 Knockout cell line (A549) Human SMURF1 1:3~1:4 Negative Online Inquiry

Background

SMURF1 Gene Knockout Cell Lines are genetically engineered cell line models that facilitate the study of the SMURF1 gene, which encodes a ubiquitin E3 ligase involved in the modulation of various cellular processes, including signal transduction pathways and cell fate decisions. By knocking out the SMURF1 gene, researchers can effectively investigate the gene's role in numerous biological functions, contributing to our understanding of cellular dynamics, particularly in the context of cancer biology, developmental processes, and immune responses.

The key function of these knockout cell lines lies in their ability to eliminate the expression of the SMURF1 protein, allowing researchers to observe downstream effects on signaling pathways such as TGF-β, Wnt, and Hippo. The switching off of SMURF1 can lead to altered cellular phenotypes, offering invaluable insights for functional studies. This investigational tool enables scientists to delineate the specific biological processes that SMURF1 influences, thereby advancing knowledge in cell biology and potential therapeutic development.

In research and clinical settings, SMURF1 Gene Knockout Cell Lines are pivotal for elucidating the implications of dysregulated ubiquitin-proteasome pathways in human diseases. Their unique application extends to drug discovery, where understanding the role of SMURF1 can uncover novel target sites for therapeutic intervention. Compared to traditional cell lines, the knockout model provides a clearer analysis of gene function, eliminating confounding factors associated with gene overexpression or partial gene function.

One of the standout advantages of our SMURF1 Gene Knockout Cell Lines is their ease of use; they are developed with a high degree of specificity and minimal off-target effects, ensuring reliable, reproducible data. Researchers benefit from a robust and versatile tool that enhances their experimental rigor, making it easier to derive impactful conclusions and hypotheses.

Ultimately, investing in SMURF1 Gene Knockout Cell Lines means equipping research laboratories with advanced tools for understanding critical biological processes at the molecular level. Our company's dedication to innovation and quality in biological research tools ensures researchers and clinicians have access to high-performance models that can drive forward solutions in health and disease management.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.