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SMPDL3A Knockout Cell Lines

Gene: SMPDL3A

Official Full Name: sphingomyelin phosphodiesterase acid like 3Aprovided by HGNC

Gene Summary: Enables phosphoric diester hydrolase activity and zinc ion binding activity. Involved in negative regulation of cGAS/STING signaling pathway and nucleoside triphosphate catabolic process. Located in extracellular exosome. Is active in extracellular space. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31413 SMPDL3A Knockout cell line (HeLa) Human SMPDL3A 1:3~1:6 Negative Online Inquiry
KO31414 SMPDL3A Knockout cell line (HCT 116) Human SMPDL3A 1:2~1:4 Negative Online Inquiry
KO31415 SMPDL3A Knockout cell line (HEK293) Human SMPDL3A 1:3~1:6 Negative Online Inquiry
KO31416 SMPDL3A Knockout cell line (A549) Human SMPDL3A 1:3~1:4 Negative Online Inquiry

Background

SMPDL3A Gene Knockout Cell Lines are specialized cellular models designed for the study of the SMPDL3A gene, which plays a critical role in cellular signaling and metabolism. These knockout cell lines have been engineered to disrupt the SMPDL3A gene, allowing researchers to investigate the biological functions of this gene in various cellular processes. The mechanism of action involves using CRISPR-Cas9 technology or similar genome-editing tools to create precise deletions in the DNA sequence, effectively silencing the expression of the SMPDL3A protein.

The scientific importance of SMPDL3A Gene Knockout Cell Lines lies in their application in the fields of cancer biology, immunology, and metabolic research. By observing the phenotypic and functional changes in cells lacking SMPDL3A, researchers can elucidate the gene's role in key pathways, including those involved in lipid metabolism and cell signaling. These insights are critical for understanding disease mechanisms and could pave the way for novel therapeutic strategies.

One of the notable advantages of using our SMPDL3A Gene Knockout Cell Lines over traditional methods, such as siRNA knockdown or pharmacological inhibitors, includes the stable and long-term loss of gene function, providing more reliable and reproducible results. This stability allows for extensive longitudinal studies and the examination of long-term cellular behavior without the confounding effects of transient gene inhibition.

For researchers and clinicians exploring the intricate dynamics of cell signaling pathways, the ability to utilize our knockout cell lines offers valuable insights that could lead to advancements in targeted therapies and personalized medicine. Moreover, they support the rigorous demands of modern research by facilitating high-throughput screening and functional assays.

As a company dedicated to innovation in biological products, we combine extensive expertise in gene editing technologies with a commitment to providing high-quality research tools. Our SMPDL3A Gene Knockout Cell Lines represent a state-of-the-art solution for unlocking the complexities of cellular function and advancing biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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