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SMARCAD1 Knockout Cell Lines

Gene: SMARCAD1

Official Full Name: SNF2 related chromatin remodeling ATPase with DExD box 1provided by HGNC

Gene Summary: This gene encodes a member of the SNF subfamily of helicase proteins. The encoded protein plays a critical role in the restoration of heterochromatin organization and propagation of epigenetic patterns following DNA replication by mediating histone H3/H4 deacetylation. Mutations in this gene are associated with adermatoglyphia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13957 SMARCAD1 Knockout cell line (HeLa) Human SMARCAD1 1:3~1:6 Negative Online Inquiry
KO13958 SMARCAD1 Knockout cell line (HCT 116) Human SMARCAD1 1:2~1:4 Negative Online Inquiry
KO13959 SMARCAD1 Knockout cell line (HEK293) Human SMARCAD1 1:3~1:6 Negative Online Inquiry
KO13960 SMARCAD1 Knockout cell line (A549) Human SMARCAD1 1:3~1:4 Negative Online Inquiry

Background

SMARCAD1 Gene Knockout Cell Lines are genetically engineered cellular models designed to facilitate the functional study of the SMARCAD1 gene by providing a platform where its expression is completely disrupted. This approach allows researchers to analyze the gene's role in various biological processes, including DNA repair, chromatin remodeling, and gene regulation, through a loss-of-function strategy. The knockout is achieved using advanced CRISPR/Cas9 genome-editing technology, which introduces specific mutations that prevent SMARCAD1 protein production.

The primary function of these cell lines is to elucidate the mechanisms by which SMARCAD1 influences cellular behavior and its implications in disease states, particularly in cancer and genetic disorders. The precise knockout of SMARCAD1 enables researchers to investigate downstream targets and pathways, thereby enhancing our understanding of cellular responses to genomic stressors. This invaluable insight can also inform therapeutic approaches, as understanding gene function is critical for developing targeted treatments.

In comparison to alternative models, such as siRNA-mediated knockdowns, SMARCAD1 Gene Knockout Cell Lines provide a more stable and complete loss of gene function, yielding reproducible results that are vital for rigorous scientific inquiry. Furthermore, the genetic modifications are performed with minimal off-target effects, ensuring higher accuracy in experimental designs.

The value of SMARCAD1 Gene Knockout Cell Lines lies in their ability to support cutting-edge research in molecular biology and therapeutic development. Researchers and clinicians can leverage this tool to strengthen their studies, driving innovations in gene therapy and cancer research. Our company specializes in developing high-quality biological products tailored for the research community, backed by rigorous technological expertise and a commitment to advancing scientific understanding.

Please note that all services are for research use only. Not intended for any clinical use.

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