Gene: SLFN11
Official Full Name: schlafen family member 11provided by HGNC
Gene Summary: Enables ATP hydrolysis activity and tRNA binding activity. Involved in several processes, including defense response to virus; negative regulation of G1/S transition of mitotic cell cycle; and replication fork arrest. Located in cytosol; nucleoplasm; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO23431 | SLFN11 Knockout cell line (HeLa) | Human | SLFN11 | 1:3~1:6 | Negative | Online Inquiry |
KO23432 | SLFN11 Knockout cell line (HEK293) | Human | SLFN11 | 1:3~1:6 | Negative | Online Inquiry |
KO23433 | SLFN11 Knockout cell line (A549) | Human | SLFN11 | 1:3~1:4 | Negative | Online Inquiry |
SLFN11 Gene Knockout Cell Lines are genetically engineered cell systems specifically designed to facilitate the study of the Schlafen family of genes, particularly SLFN11, which plays a critical role in immune response and viral defense mechanisms. These cell lines are created using advanced CRISPR-Cas9 gene-editing technology, resulting in targeted deletions of the SLFN11 gene. By eliminating SLFN11 expression, researchers can investigate the gene's functional implications in various biological contexts and disease states.
The primary function of SLFN11 is linked to its involvement in cellular responses to viral infections, particularly in modulating the innate immune response and influencing the susceptibility of cells to viral replication. By utilizing these knockout cell lines, researchers gain valuable insights into how SLFN11 affects cell viability, proliferation, and viral resistance. This enables the identification of potential therapeutic targets and the development of new strategies to combat viral diseases and enhance antitumor immunity.
In research and clinical settings, SLFN11 Gene Knockout Cell Lines are invaluable tools for elucidating the roles of Schlafen proteins in disease pathology, especially concerning cancers and viral infections. Their applications range from basic research on gene function to preclinical studies aimed at evaluating novel antiviral drugs or immunotherapies. Moreover, the ability to specifically manipulate the SLFN11 gene provides a level of control and specificity that is crucial in experimental settings.
Compared to traditional cell lines, these knockout models offer a unique advantage by providing a precise genetic background for studying gene function without confounding variables. This specificity can significantly enhance the reliability of experimental results and lead to more robust findings that can be translated into clinical applications.
For researchers and clinicians focused on advancing our understanding of gene functions and developing therapeutic interventions, SLFN11 Gene Knockout Cell Lines represent a powerful and essential resource. They allow for in-depth investigation into the molecular underpinnings of viral resistance and immune regulation.
At [Your Company Name], we are dedicated to delivering high-quality, innovative biological products that empower scientists in their research endeavors. Our expertise in gene editing technologies ensures that our SLFN11 Gene Knockout Cell Lines meet the highest standards for functionality and reliability, supporting advancements in biomedical research.
Please note that all services are for research use only. Not intended for any clinical use.
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