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SLC6A6 Knockout Cell Lines

Gene: SLC6A6

Official Full Name: solute carrier family 6 member 6provided by HGNC

Gene Summary: This gene encodes a multi-pass membrane protein that is a member of a family of sodium and chloride-ion dependent transporters. The encoded protein transports taurine and beta-alanine. There is a pseudogene for this gene on chromosome 21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00143 SLC6A6 Knockout cell line (THP-1) Human SLC6A6 1:2-1:4 Negative Online Inquiry
KO35394 SLC6A6 Knockout cell line (HeLa) Human SLC6A6 1:3~1:6 Negative Online Inquiry
KO35395 SLC6A6 Knockout cell line (HCT 116) Human SLC6A6 1:2~1:4 Negative Online Inquiry
KO35396 SLC6A6 Knockout cell line (HEK293) Human SLC6A6 1:3~1:6 Negative Online Inquiry
KO35397 SLC6A6 Knockout cell line (A549) Human SLC6A6 1:3~1:4 Negative Online Inquiry

Background

SLC6A6 Gene Knockout Cell Lines are genetically engineered cell lines created to lack the SLC6A6 gene, which encodes the sodium-coupled neutral amino acid transporter (SNAT) 1. These knockout cell lines provide a valuable tool for researchers studying the role of SLC6A6 in various biological processes, including amino acid transport, metabolic regulation, and neurotransmission. By depleting the expression of SLC6A6, these cell lines allow for the analysis of the gene's function and its implications in health and disease, facilitating insights into disorders tied to amino acid imbalances or transport deficiencies.

The primary function of SLC6A6 involves the uptake of neutral amino acids, particularly alanine, into cells, influencing processes such as energy metabolism and neurotransmission. By utilizing knockout models, scientists can investigate the mechanistic pathways that are disrupted in the absence of SLC6A6, providing a clearer understanding of its role in physiological and pathological states. In research settings, these cell lines are pivotal for drug development and testing, where they help elucidate the transport mechanisms of various pharmaceuticals and their potential therapeutic effects on conditions like autism spectrum disorders and metabolic syndromes.

Compared to alternative models, SLC6A6 Gene Knockout Cell Lines offer a higher specificity for studying the particular functions of the SLC6A6 gene without the confounding effects of other transporters. Additionally, the ability to induce or inhibit specific pathways uniquely positions these models for in-depth mechanistic exploration.

The value of these knockout cell lines extends to both researchers and clinicians alike, as they enable the development of targeted therapeutic strategies and inform clinical decisions based on genetic profiling. With the growing emphasis on precision medicine, possessing an in-depth understanding of amino acid transporters like SLC6A6 may enhance patient care through tailored interventions.

Our company specializes in providing high-quality genetic models and solutions tailored for biomedical research, ensuring that our products, including SLC6A6 Gene Knockout Cell Lines, are rigorously validated for scientific accuracy and experimental reliability. Our expertise enables us to meet the diverse needs of the research community, promoting groundbreaking discoveries in the realm of molecular and cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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