Gene: SLC6A15
Official Full Name: solute carrier family 6 member 15provided by HGNC
Gene Summary: This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14105 | SLC6A15 Knockout cell line (HeLa) | Human | SLC6A15 | 1:3~1:6 | Negative | Online Inquiry |
KO14106 | SLC6A15 Knockout cell line (HEK293) | Human | SLC6A15 | 1:3~1:6 | Negative | Online Inquiry |
KO14107 | SLC6A15 Knockout cell line (A549) | Human | SLC6A15 | 1:3~1:4 | Negative | Online Inquiry |
SLC6A15 Gene Knockout Cell Lines are genetically engineered cell models that have had the SLC6A15 gene disrupted, allowing researchers to study the functional role of this gene in various biological processes. The SLC6A15 gene encodes a sodium-dependent neutral amino acid transporter, which is crucial for neurotransmitter regulation and amino acid homeostasis in mammalian cells. By knocking out this gene, these cell lines provide a platform for investigating the implications of SLC6A15 disruptions on neuronal growth, synaptic function, and metabolic pathways, making them an indispensable tool in neuroscience, pharmacology, and metabolic research.
The key functions of these cell lines stem from the enhanced understanding of gene function through loss-of-function studies. Through techniques like transfection and CRISPR-Cas9 gene editing, these cell lines are designed to elucidate the molecular mechanisms underpinning amino acid transport and its associations with neurological disorders like depression and autism. Researchers can utilize these cell lines to explore the therapeutic potential of targeting SLC6A15 and study compensatory mechanisms in amino acid transport.
The scientific importance of SLC6A15 Gene Knockout Cell Lines extends to their applications in drug discovery and disease modeling. By providing insights into the molecular mechanisms of synaptic activity and metabolism, these cell lines are instrumental in characterizing the effects of pharmacological agents aimed at modulating amino acid transport in clinical settings. Additionally, they can serve as valuable models for testing the efficacy of new therapeutics targeting associated neurological conditions.
What sets SLC6A15 Gene Knockout Cell Lines apart from alternatives is their precise genetic modification, which allows for enhanced reproducibility and specificity in experiments. The complete knockout of the SLC6A15 function enables researchers to draw clear conclusions about the gene's role, reducing the ambiguity often associated with partial inhibition strategies. Furthermore, these cell lines are designed to be easy to cultivate and genetically stable, saving valuable time and resources in experimental setups.
This product is invaluable to researchers and clinicians who are engaged in neuroscience, drug discovery, and metabolic research, as it bridges the gap between fundamental research and therapeutic discovery. Understanding the mechanics of SLC6A15 facilitates the development of targeted therapies that could lead to significant improvements in treating neurological disorders.
Our company prides itself on its commitment to scientific excellence and innovation in biological products, providing high-quality gene knockout cell lines that empower researchers to push the boundaries of discovery in their fields. With a focus on reliability and cutting-edge technology, we are dedicated to supporting your research needs with our expertly developed cell line offerings.
Please note that all services are for research use only. Not intended for any clinical use.
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