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SLC66A1 Knockout Cell Lines

Gene: SLC66A1

Official Full Name: solute carrier family 66 member 1provided by HGNC

Gene Summary: Enables L-arginine transmembrane transporter activity; L-histidine transmembrane transporter activity; and L-lysine transmembrane transporter activity. Involved in L-amino acid transport and intracellular amino acid homeostasis. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20133 SLC66A1 Knockout cell line (HeLa) Human SLC66A1 1:3~1:6 Negative Online Inquiry
KO20134 SLC66A1 Knockout cell line (HCT 116) Human SLC66A1 1:2~1:4 Negative Online Inquiry
KO20135 SLC66A1 Knockout cell line (HEK293) Human SLC66A1 1:3~1:6 Negative Online Inquiry
KO20136 SLC66A1 Knockout cell line (A549) Human SLC66A1 1:3~1:4 Negative Online Inquiry

Background

SLC66A1 Gene Knockout Cell Lines are engineered cellular systems designed to selectively disrupt the SLC66A1 gene, which encodes a transporter protein crucial for the regulation of neurotransmitter uptake and lysosomal transport. These knockout cell lines are created using advanced genome editing technologies, such as CRISPR-Cas9, permitting researchers to elucidate the role of the SLC66A1 gene in cell physiology and its implications in various pathophysiological conditions.

The primary function of SLC66A1 involves mediating the transport of neurotransmitters across cellular membranes, thereby influencing synaptic function and overall neural activity. By utilizing SLC66A1 Gene Knockout Cell Lines, researchers can investigate the consequences of gene disruption on cellular behavior, such as altered neurotransmitter levels, changes in signaling pathways, and impacts on metabolic processes. This contributes to understanding the molecular mechanisms underlying diseases like neurodegenerative disorders and metabolic syndromes, where dysregulation of transporters is often observed.

In addition to being a robust tool in basic research, the SLC66A1 knockout cell lines possess significant scientific importance in pharmaceutical development, allowing for high-throughput screening of compounds targeting SLC66A1-related pathways. Compared to traditional knockdown methods, such as siRNA or shRNA interventions, these knockout cell lines provide a more stable and permanent solution to studying gene function, ultimately leading to more reproducible results.

Researchers and clinicians will find exceptional value in the SLC66A1 Gene Knockout Cell Lines as they provide a reliable platform for in-depth studies into neurotransmitter dynamics, potential therapeutic targets, and the underlying mechanisms of related diseases. This product bridges the gap between basic science and clinical application, supporting projects that can lead to novel therapeutic strategies.

Our company, committed to cutting-edge biotechnological advancements, offers a range of genetically modified cell lines, ensuring high-quality, reliable biological tools for the scientific community. Our expertise in creating precise and efficient gene knockout systems facilitates groundbreaking research and development in various biological fields.

Please note that all services are for research use only. Not intended for any clinical use.

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