Gene: SLC49A4
Official Full Name: solute carrier family 49 member 4provided by HGNC
Gene Summary: This gene encodes a membrane-bound protein from the major facilitator superfamily of transporters. Disruption of this gene by translocation has been associated with haplo-insufficiency and renal cell carcinomas. Alternatively spliced transcript variants have been described, but their biological validity has not yet been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00330 | SLC49A4 Knockout cell line (HeLa) | Human | SLC49A4 | 1:3~1:6 | Negative | Online Inquiry |
KO05942 | SLC49A4 Knockout cell line (HCT 116) | Human | SLC49A4 | 1:2~1:4 | Negative | Online Inquiry |
KO05943 | SLC49A4 Knockout cell line (HEK293) | Human | SLC49A4 | 1:3~1:6 | Negative | Online Inquiry |
KO05944 | SLC49A4 Knockout cell line (A549) | Human | SLC49A4 | 1:3~1:4 | Negative | Online Inquiry |
SLC49A4 Gene Knockout Cell Lines are precisely engineered cellular models that have had the SLC49A4 gene disrupted using CRISPR-Cas9 technology. The SLC49A4 gene is implicated in various physiological processes, notably in the transport of solutes across cellular membranes, and its knockout allows for the investigation of downstream effects on cellular function and metabolism. This genetic modification creates a valuable tool for researchers who aim to elucidate the roles of specific proteins and transport mechanisms in health and disease.
The primary functions of these cell lines include enabling researchers to study the phenotypic and biochemical changes that arise from the absence of SLC49A4. By investigating these alterations, scientists can gain insights into metabolic pathways, disease processes, and the underlying mechanisms of conditions such as metabolic disorders and certain types of cancer. The capability to derive a comprehensive understanding of SLC49A4’s role in cellular physiology offers potential breakthroughs in therapeutic strategies.
From a scientific perspective, SLC49A4 Gene Knockout Cell Lines provide unparalleled avenues for research in both basic and translational sciences. This product's adaptability for use in high-throughput screening and its compatibility with various assays make it an essential asset for laboratories focused on pharmacology, toxicology, and gene therapy.
Compared to alternative models, such as short interfering RNA (siRNA) or transient transfection techniques, the knockout strategy ensures a stable and consistent loss of function that can be maintained over time. This feature not only enhances reproducibility but also allows for long-term studies that are often crucial for drug development and toxicological assessments.
For researchers and clinicians dedicated to unveiling the complexities of cellular functions or seeking advanced models for preclinical studies, the SLC49A4 Gene Knockout Cell Lines present a valuable and innovative solution. They stand at the forefront of modern biological research, which is underscored by our company’s commitment to delivering high-quality, cutting-edge tools that empower scientific discovery and innovation. With our deep expertise in genetic engineering and cellular models, we are dedicated to supporting life sciences professionals in their quest for knowledge and therapeutic advances.
Please note that all services are for research use only. Not intended for any clinical use.
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