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SLC35B2 Knockout Cell Lines

Gene: SLC35B2

Official Full Name: solute carrier family 35 member B2provided by HGNC

Gene Summary: Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03039 SLC35B2 Knockout cell line (HeLa) Human SLC35B2 1:3~1:6 Negative Online Inquiry
KO03040 SLC35B2 Knockout cell line (HCT 116) Human SLC35B2 1:2~1:4 Negative Online Inquiry
KO03041 SLC35B2 Knockout cell line (HEK293) Human SLC35B2 1:3~1:6 Negative Online Inquiry
KO03042 SLC35B2 Knockout cell line (A549) Human SLC35B2 1:3~1:4 Negative Online Inquiry

Background

SLC35B2 Gene Knockout Cell Lines are specifically engineered cellular models designed to study the function of the SLC35B2 gene, which is vital for nucleotide sugar transport in the endoplasmic reticulum (ER). By utilizing CRISPR-Cas9 technology, these cell lines have had the SLC35B2 gene effectively disrupted, allowing researchers to investigate the gene's biological roles and implications in various physiological and pathological processes.

The key function of these knockout cell lines lies in their ability to provide a controlled environment for examining the biochemical pathways influenced by SLC35B2. By eliminating the gene's expression, researchers can elucidate its impact on cellular metabolism, glycosylation processes, and potential contributions to disease states such as congenital disorders of glycosylation, metabolic diseases, and cancer. The mechanistic insights gained through these models can facilitate the identification of novel therapeutic targets and biomarkers.

In clinical and research settings, SLC35B2 Gene Knockout Cell Lines prove to be invaluable tools for drug discovery and validation. Their specificity allows for high-throughput screening of compounds that may rectify or modulate the functional deficits caused by SLC35B2 deletion. Compared to traditional methods, these knockout models offer greater accuracy and reproducibility, minimizing background interference and enhancing the reliability of experimental results.

The unique selling points of SLC35B2 Gene Knockout Cell Lines include their ready-to-use format, extensive characterization data, and adaptability to various experimental setups. Researchers, clinicians, and pharmaceutical companies benefit from the ability to directly manipulate and analyze the specific gene's role in live cell systems without the need for extensive preliminary development.

By partnering with a company renowned for its expertise in genetic engineering and cell biology, users can confidently integrate SLC35B2 Gene Knockout Cell Lines into their research programs, propelling their investigations into new realms of genetic function and therapeutic intervention.

Please note that all services are for research use only. Not intended for any clinical use.

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