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SLC30A3 Knockout Cell Lines

Gene: SLC30A3

Official Full Name: solute carrier family 30 member 3provided by HGNC

Gene Summary: Enables zinc ion transmembrane transporter activity. Involved in zinc ion import into lysosome. Located in late endosome and synaptic vesicle. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34470 SLC30A3 Knockout cell line (HCT 116) Human SLC30A3 1:2~1:4 Negative Online Inquiry
KO34471 SLC30A3 Knockout cell line (HEK293) Human SLC30A3 1:3~1:6 Negative Online Inquiry
KO34472 SLC30A3 Knockout cell line (A549) Human SLC30A3 1:3~1:4 Negative Online Inquiry

Background

SLC30A3 Gene Knockout Cell Lines are genetically engineered cell lines in which the SLC30A3 gene has been deactivated or "knocked out," allowing for detailed studies of the biological functions mediated by this gene. SLC30A3 encodes for a zinc transporter, which plays a crucial role in maintaining zinc homeostasis within cells. The knockout of this gene enables researchers to investigate the physiological and pathological roles of zinc transport in various cellular processes, including cell signaling, apoptosis, and metabolic regulation.

These cell lines function by providing a controlled environment to study the consequences of SLC30A3 deficiency. Mechanistically, the knockout leads to alterations in zinc transport efficiency, allowing scientists to observe resulting changes in cellular zinc concentrations and their effects on downstream signaling pathways. This is particularly important in understanding diseases where zinc dysregulation is implicated, such as diabetes and neurodegenerative disorders.

From a scientific perspective, SLC30A3 Gene Knockout Cell Lines are invaluable in both research and clinical applications. They serve as powerful tools for exploring novel therapeutic strategies that target zinc transport mechanisms. Compared to alternative models, these cell lines offer a more precise and reproducible method for studying specific genetic contributions and their potential role in disease progression.

Researchers and clinicians will find significant value in utilizing these knockout cell lines, as they enable the elucidation of molecular mechanisms that could lead to potential breakthroughs in treatment methodologies. The specificity of the knockout can dramatically reduce variability in experiments, providing clearer insights into the impacts of zinc transport and homeostasis.

With a commitment to advancing biological research, our company specializes in developing high-quality, genetically modified cell lines tailored for precise applications. We assure that each product is rigorously validated and optimized for robust performance in transformative scientific research.

Please note that all services are for research use only. Not intended for any clinical use.

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