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SLC29A3 Knockout Cell Lines

Gene: SLC29A3

Official Full Name: solute carrier family 29 member 3provided by HGNC

Gene Summary: This gene encodes a nucleoside transporter. The encoded protein plays a role in cellular uptake of nucleosides, nucleobases, and their related analogs. Mutations in this gene have been associated with H syndrome, which is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism. A related disorder, PHID (pigmented hypertrichosis with insulin-dependent diabetes mellitus), has also been associated with mutations at this locus. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00357 SLC29A3 Knockout cell line (HeLa) Human SLC29A3 1:3~1:6 Negative Online Inquiry
KO20129 SLC29A3 Knockout cell line (HCT 116) Human SLC29A3 1:2~1:4 Negative Online Inquiry
KO20130 SLC29A3 Knockout cell line (HEK293) Human SLC29A3 1:3~1:6 Negative Online Inquiry
KO20131 SLC29A3 Knockout cell line (A549) Human SLC29A3 1:3~1:4 Negative Online Inquiry

Background

SLC29A3 Gene Knockout Cell Lines are engineered biological models specifically developed to lack the SLC29A3 gene expression, which encodes for the equilibrative nucleoside transporter 3. This gene plays a critical role in extracellular nucleoside transport and has been implicated in various physiological and pathological processes, including immune responses, metabolic syndromes, and cancer progression. By utilizing these knockout cell lines, researchers can effectively dissect the functional implications of SLC29A3 deficiency, elucidating its role in cellular mechanisms and disease models.

The primary function of SLC29A3 involves the regulation of nucleoside levels within cells, impacting nucleic acid metabolism and signaling pathways. By observing cellular behaviors and interactions in the absence of this transporter, scientists can gain insights into altered metabolic states and potential therapeutic targets, particularly in tumors or inflammatory conditions. These knockouts serve as critical tools for studying the gene's contribution to cellular functions and the biochemical pathways it influences, ultimately aiding in the identification of novel intervention strategies.

In research and clinical settings, the SLC29A3 Gene Knockout Cell Lines provide invaluable models for investigating drug transport, therapeutic efficacy, and disease mechanisms. As precision medicine advances, understanding how variances in nucleoside transport impact individual patient responses becomes increasingly important, making these cell lines particularly relevant for pharmacogenomic studies and drug development.

Compared to alternative models, our SLC29A3 Gene Knockout Cell Lines are rigorously validated, demonstrating consistent and reproducible results across various studies. Their specificity eliminates confounding factors commonly associated with partial gene inhibition, ensuring high-fidelity experimental outcomes. Furthermore, they can be tailored to diverse biological research fields, from cancer biology to neurobiology, thus enhancing their versatility.

Researchers and clinicians can leverage these cell lines to accelerate discoveries and optimize therapeutic approaches, ultimately driving innovation in treatment modalities. Our company specializes in high-quality biological products with a commitment to advancing scientific research, ensuring that our SLC29A3 Gene Knockout Cell Lines are not only a valuable addition to any research toolkit but also contribute meaningfully to the broader understanding of gene function and regulation in human health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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