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SLC27A1 Knockout Cell Lines

Gene: SLC27A1

Official Full Name: solute carrier family 27 member 1provided by HGNC

Gene Summary: Enables biotin transmembrane transporter activity; efflux transmembrane transporter activity; and long-chain fatty acid transmembrane transporter activity. Involved in several processes, including glycerophospholipid biosynthetic process; lipid transport across blood-brain barrier; and monocarboxylic acid transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02674 SLC27A1 Knockout cell line (HeLa) Human SLC27A1 1:3~1:6 Negative Online Inquiry
KO02675 SLC27A1 Knockout cell line (HCT 116) Human SLC27A1 1:2~1:4 Negative Online Inquiry
KO02676 SLC27A1 Knockout cell line (HEK293) Human SLC27A1 1:3~1:6 Negative Online Inquiry
KO02677 SLC27A1 Knockout cell line (A549) Human SLC27A1 1:3~1:4 Negative Online Inquiry

Background

SLC27A1 Gene Knockout Cell Lines are specifically engineered cell lines in which the SLC27A1 gene, responsible for encoding the fatty acid transport protein 1, has been disrupted. This genetic modification enables researchers to study the effects of SLC27A1 loss on cellular metabolism, lipid homeostasis, and associated physiological processes. By effectively silencing this gene, the knockout cell lines provide a powerful tool for investigating the role of fatty acid transport in health and disease.

The functionality of SLC27A1 knockout cell lines is derived from their ability to create a controlled environment in which the impacts of absent SLC27A1 expression can be thoroughly assessed. This includes examining alterations in fatty acid uptake, oxidative stress response, and overall cellular metabolism. The mechanisms of disruption lay the groundwork for investigations into pathways associated with metabolic disorders, cardiovascular diseases, and certain cancers.

From a scientific perspective, SLC27A1 knockout cell lines present significant applications in both research and clinical settings. They are instrumental in the exploration of lipid metabolism, the development of therapeutic strategies targeting metabolic syndromes, and in drug discovery processes that focus on modulating fatty acid transport mechanisms. Their role in elucidating the basic biology of lipids in disease states enhances their value to the research community.

One distinctive advantage of SLC27A1 knockout cell lines is their specificity and reliability compared to other models. Unlike conventional cell lines that may express varying levels of SLC27A1, the knockout lines provide a clear, unequivocal view of cellular processes without interference from residual protein activity. This specificity enhances the reproducibility of experiments and allows for more robust data interpretation.

Researchers, clinicians, and pharmaceutical companies will find SLC27A1 gene knockout cell lines invaluable due to their capacity to reveal insights into lipid-related disorders. By leveraging these tools, users can accelerate the pace of discovery, develop novel therapeutic approaches, and ultimately advance the understanding of lipid metabolism in human health.

At [Company Name], we take pride in our expertise in biological products and our commitment to providing high-quality, meticulously validated SLC27A1 gene knockout cell lines designed to facilitate advanced research and innovative discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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