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SLC25A25 Knockout Cell Lines

Gene: SLC25A25

Official Full Name: solute carrier family 25 member 25provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the family of calcium-binding mitochondrial carriers, with a characteristic mitochondrial carrier domain at the C-terminus. These proteins are found in the inner membranes of mitochondria, and function as transport proteins. They shuttle metabolites, nucleotides and cofactors through the mitochondrial membrane and thereby connect and/or regulate cytoplasm and matrix functions. This protein may function as an ATP-Mg/Pi carrier that mediates the transport of Mg-ATP in exchange for phosphate, and likely responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria. Alternatively spliced transcript variants encoding different isoforms with a common C-terminus but variable N-termini have been described for this gene. [provided by RefSeq, Jul 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30763 SLC25A25 Knockout cell line (HeLa) Human SLC25A25 1:3~1:6 Negative Online Inquiry
KO30764 SLC25A25 Knockout cell line (HCT 116) Human SLC25A25 1:2~1:4 Negative Online Inquiry
KO30765 SLC25A25 Knockout cell line (HEK293) Human SLC25A25 1:3~1:6 Negative Online Inquiry
KO30766 SLC25A25 Knockout cell line (A549) Human SLC25A25 1:3~1:4 Negative Online Inquiry

Background

SLC25A25 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to study the function and regulation of the SLC25A25 gene, which encodes a mitochondrial transporter involved in the transport of metabolites across the mitochondrial membrane. By employing CRISPR-Cas9 technology, these cell lines have been engineered to lack the SLC25A25 gene, allowing researchers to investigate the gene's role in metabolic pathways, mitochondrial function, and cellular energy homeostasis.

The primary function of these knockout cell lines is to provide a model for understanding how the absence of SLC25A25 impacts cellular processes, including ATP production, reactive oxygen species (ROS) generation, and overall mitochondrial integrity. Researchers can use these models to elucidate the gene's involvement in various metabolic disorders and disease states, particularly those linked to mitochondrial dysfunction. By comparing knockout and wild-type cell lines, scientists can gain insights into compensatory mechanisms and the potential impact of SLC25A25 on cellular signaling pathways.

The significance of SLC25A25 Gene Knockout Cell Lines extends beyond basic research, as they hold the potential for translational applications in drug development and disease modeling. Their use can facilitate the screening of pharmacological agents that target mitochondrial pathways, ultimately leading to novel therapeutic strategies for conditions associated with mitochondrial dysfunction.

One of the unique advantages of our SLC25A25 Gene Knockout Cell Lines is their high specificity and reliability in results, providing clear and reproducible data compared to conventional RNA interference methods. Additionally, the isogenic nature of these cell lines allows for more accurate assessments of gene function without the confounding effects of genetic variability.

For researchers and clinicians seeking to deepen their understanding of mitochondrial biology and its implications for human health, our SLC25A25 Gene Knockout Cell Lines represent a pivotal tool. Supported by our company’s expertise in genetic engineering and molecular biology, these products not only advance scientific knowledge but also contribute to the development of innovative solutions in the field of medicine and biotechnology.

Please note that all services are for research use only. Not intended for any clinical use.

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