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SLC25A20 Knockout Cell Lines

Gene: SLC25A20

Official Full Name: solute carrier family 25 member 20provided by HGNC

Gene Summary: This gene product is one of several closely related mitochondrial-membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space. This protein mediates the transport of acylcarnitines into mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Mutations in this gene are associated with carnitine-acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38712 SLC25A20 Knockout cell line (HeLa) Human SLC25A20 1:3~1:6 Negative Online Inquiry
KO38713 SLC25A20 Knockout cell line (HCT 116) Human SLC25A20 1:2~1:4 Negative Online Inquiry
KO38714 SLC25A20 Knockout cell line (HEK293) Human SLC25A20 1:3~1:6 Negative Online Inquiry
KO38715 SLC25A20 Knockout cell line (A549) Human SLC25A20 1:3~1:4 Negative Online Inquiry

Background

SLC25A20 Gene Knockout Cell Lines are engineered cell lines designed to study the functional implications of the SLC25A20 gene, which encodes the mitochondrial carrier protein known as CAC. This protein plays a pivotal role in the transport of long-chain fatty acids across the mitochondrial inner membrane, thus contributing to cellular energy metabolism and the regulation of metabolic pathways.

The key function of these knockout cell lines is to determine the specific roles of SLC25A20 in fatty acid metabolism and mitochondrial function. By selectively disabling the SLC25A20 gene, researchers can explore the resultant metabolic alterations, including shifts in lipid profile, energy production, and overall cellular health. This provides significant insights into conditions linked to mitochondrial dysfunction, such as metabolic syndromes, cardiovascular diseases, and certain neurological disorders.

The scientific importance of SLC25A20 Gene Knockout Cell Lines extends to both fundamental and applied research. In clinical settings, these cell lines serve as models for drug screening, elucidating potential therapeutic targets for metabolic diseases. The research community relies on such models to generate evidence-based insights and to create innovative treatment modalities.

One of the distinct advantages of our SLC25A20 Gene Knockout Cell Lines is their robustness and reproducibility, paired with extensive validation of SLC25A20 disruption. Unlike traditional knockdown approaches, which can lead to incomplete loss of function, these knockout lines offer a comprehensive and definitive model for studying gene function. Additionally, our cell lines come with detailed characterization data, allowing researchers to confidently interpret experimental outcomes.

For researchers and clinicians targeting mitochondrial dysfunction and related metabolic disorders, SLC25A20 Gene Knockout Cell Lines present a valuable resource. The insights garnered from these models can drive significant advancements in understanding the etiology of metabolic diseases, aligning with the broader aim of enhancing patient care.

Our company possesses extensive expertise in developing high-quality biological products, tailored to the needs of the scientific community, ensuring that you have reliable tools for transformative research.

Please note that all services are for research use only. Not intended for any clinical use.

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