Gene: SLC25A13
Official Full Name: solute carrier family 25 member 13provided by HGNC
Gene Summary: This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00180 | SLC25A13 Knockout cell line (HEK293) | Human | SLC25A13 | 1:3~1:6 | Negative | Online Inquiry |
KO03586 | SLC25A13 Knockout cell line (HeLa) | Human | SLC25A13 | 1:3~1:6 | Negative | Online Inquiry |
KO03587 | SLC25A13 Knockout cell line (HCT 116) | Human | SLC25A13 | 1:2~1:4 | Negative | Online Inquiry |
KO03588 | SLC25A13 Knockout cell line (A549) | Human | SLC25A13 | 1:3~1:4 | Negative | Online Inquiry |
SLC25A13 Gene Knockout Cell Lines are genetically engineered cell lines specifically modified to disrupt the SLC25A13 gene, which encodes the mitochondrial aspartate/glutamate carrier, involved in key metabolic pathways and mitochondrial function. By creating these knockout models, researchers can study the physiological and pathological impacts of the gene's absence, elucidating its role in various developmental processes and metabolic diseases.
These cell lines function effectively as critical tools in understanding the mechanisms underlying mitochondrial dysfunction, particularly in the context of disorders like citrullinemia and other metabolic syndromes. With the SLC25A13 gene knocked out, researchers can explore the effects on cellular metabolism, energy production, and the physiological roles of aspartate and glutamate transport in health and disease. This allows for accelerated discovery in terms of therapeutic targets and potential treatment strategies.
Scientifically important for both clinical and experimental research, these cell lines can help in drug development and the assessment of therapeutic interventions, offering a robust platform for high-throughput screening and metabolic studies. Unlike conventional cell lines that may retain normal SLC25A13 function, our knockout models provide a distinct advantage by presenting a clear, controlled variable for researchers to manipulate.
The unique selling points of SLC25A13 Gene Knockout Cell Lines lie in their specificity, reliability, and consistency. They eliminate background interference from the SLC25A13 gene, enabling researchers to obtain accurate and reproducible results.
For researchers, clinicians, and biotech professionals searching for models that streamline the study of metabolic disorders, these cell lines represent invaluable tools. By utilizing our expertly developed knockout models, users can propel their research forward into identifying novel therapeutic approaches and gain deeper insights into mitochondrial biology.
As a leader in providing advanced biological products, our company is committed to delivering high-quality, innovative research tools that empower the scientific community. We harness cutting-edge genetic engineering technologies to ensure that our cell lines are of the highest standard, facilitating discovery and innovation in life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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