Gene: SLC15A1
Official Full Name: solute carrier family 15 member 1provided by HGNC
Gene Summary: This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00278 | SLC15A1 Knockout cell line (HeLa) | Human | SLC15A1 | 1:3~1:6 | Negative | Online Inquiry |
KO35372 | SLC15A1 Knockout cell line (HCT 116) | Human | SLC15A1 | 1:2~1:4 | Negative | Online Inquiry |
SLC15A1 Gene Knockout Cell Lines represent a groundbreaking resource in genetic research, specifically designed to facilitate studies of the SLC15A1 gene, which encodes a protein essential for the transport of various solutes across cellular membranes. These knockout cell lines have been engineered using advanced genomic editing techniques, such as CRISPR/Cas9 technology, to abrogate the expression of the SLC15A1 gene, allowing researchers to investigate the functional roles of this gene and its associated transport mechanisms in a controlled environment.
The primary function of these cell lines is to eliminate SLC15A1 expression and observe the resulting phenotypic changes, thus providing a powerful tool for elucidating the molecular pathways that govern nutrient absorption and immune response. SLC15A1 plays a crucial role in the transport of di- and tri-peptides, and by employing these knockout models, researchers can better understand the implications of this gene in conditions such as inflammatory bowel disease, antibiotic resistance, and other metabolic disorders.
The scientific importance of SLC15A1 Gene Knockout Cell Lines extends into both basic and applied research, enabling comprehensive investigations into gene function and the pathways involved in drug absorption and metabolism. Clinically, these models support the exploration of therapeutic targets for improving drug efficacy and minimizing side effects associated with transport-related disorders.
Compared to traditional cell lines, SLC15A1 Gene Knockout Cell Lines offer unique advantages, including precise genetic modifications, reproducibility in experimental setups, and the ability to use these models in high-throughput screening for drug discovery and development. This specificity allows for more accurate biological interpretations and reduces the variability commonly encountered in non-knockout lines.
For researchers and clinicians alike, these knockout cell lines are invaluable for advancing knowledge in pharmacogenomics and therapeutic strategies, making them essential for any laboratory focused on genetic research or clinical applications. Our company prides itself on delivering high-quality, meticulously validated biological products, ensuring our customers have access to innovative tools that drive scientific advancement.
Please note that all services are for research use only. Not intended for any clinical use.
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