Gene: SIVA1
Official Full Name: SIVA1 apoptosis inducing factorprovided by HGNC
Gene Summary: This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14132 | SIVA1 Knockout cell line (HeLa) | Human | SIVA1 | 1:3~1:6 | Negative | Online Inquiry |
KO14133 | SIVA1 Knockout cell line (HCT 116) | Human | SIVA1 | 1:2~1:4 | Negative | Online Inquiry |
KO14134 | SIVA1 Knockout cell line (HEK293) | Human | SIVA1 | 1:3~1:6 | Negative | Online Inquiry |
KO14135 | SIVA1 Knockout cell line (A549) | Human | SIVA1 | 1:3~1:4 | Negative | Online Inquiry |
SIVA1 Gene Knockout Cell Lines are genetically engineered cellular models that have been specifically designed to lack the SIVA1 gene, which plays a crucial role in apoptosis and T-cell activation. By utilizing CRISPR/Cas9 gene editing technologies, these cell lines enable researchers to study the function of the SIVA1 gene in a controlled environment, providing insights into its role in cellular signaling and the immune response.
The key function of SIVA1 is its involvement in apoptosis regulation, particularly within T-lymphocytes. The knockout of this gene allows for the investigation of alternative cellular pathways and mechanisms that influence cell survival and death. This can be particularly illuminating in contexts such as cancer research, where the understanding of apoptosis can lead to the development of novel therapeutic strategies. Furthermore, SIVA1 knockout cell lines serve as invaluable tools for analyzing T-cell dynamics in autoimmune diseases and immunotherapy, giving insight into potential therapeutic targets and improving patient outcomes.
From a scientific standpoint, SIVA1 Gene Knockout Cell Lines hold substantial importance in both research and clinical settings. They facilitate the exploration of cellular responses to various stimuli, assisting in the screening of drug candidates or immunomodulators. In contrast to traditional techniques, such as gene silencing or overexpression systems, our knockout model offers a more robust and defined approach for dissecting gene function.
The distinct advantages of our SIVA1 knockout cell lines over alternatives include their high specificity, reproducibility, and ease of use. Researchers can rely on these cell lines to consistently yield reliable data, reducing the potential for variability associated with transient expression models. Additionally, the availability of pre-validated lines accelerates research timelines, allowing users to focus on experimental design rather than cell line optimization.
Ultimately, SIVA1 Gene Knockout Cell Lines are a valuable asset for researchers and clinicians aiming to advance their understanding of cellular processes and develop innovative treatment strategies. With our commitment to providing high-quality, reliable biological products and unsurpassed expertise in gene editing technologies, our offerings stand at the forefront of scientific research, empowering users to push the boundaries of discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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