Gene: SHISA3
Official Full Name: shisa family member 3provided by HGNC
Gene Summary: This gene encodes a single-transmembrane protein which is one of nine members of a family of transmembrane adaptors that modulate both WNT and FGF signaling by blocking the maturation and transport of their receptors to the cell surface. Members of this family contain an N-terminal cysteine-rich domain with a distinct cysteine pattern, a single transmembrane domain, and a C-terminal proline-rich, low complexity region. The encoded protein acts as a tumor suppressor by accelerating beta-catenin degradation. [provided by RefSeq, Jul 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21764 | SHISA3 Knockout cell line (HEK293) | Human | SHISA3 | 1:3~1:6 | Negative | Online Inquiry |
SHISA3 Gene Knockout Cell Lines are genetically modified cellular models specifically designed to study the function of the SHISA3 gene, which plays a critical role in various physiological processes, including cell signaling and proliferation. These knockout cell lines are created using advanced CRISPR-Cas9 technology, allowing for the precise disruption of the SHISA3 gene sequence, thus facilitating in-depth investigations of its biological implications. By removing the gene's expression, researchers are equipped to observe changes in cellular behavior, signaling pathways, and overall cellular interactions.
The primary mechanism by which SHISA3 influences cell behavior involves its involvement in the modulation of key signaling pathways, including those reliant on G-protein coupled receptors (GPCRs). Through its regulatory function, SHISA3 can either enhance or inhibit signaling cascades, making it a vital target for research in areas such as cancer biology, neurobiology, and developmental biology. The ability to study cell lines lacking SHISA3 provides insight into the gene's role in disease contexts, aiding in the identification of potential therapeutic targets or biomarkers.
In scientific research and clinical applications, SHISA3 Gene Knockout Cell Lines represent a powerful tool for elucidating gene function and understanding disease mechanisms. These cell lines facilitate extensive screening of drug candidates and the exploration of novel therapeutic strategies, significantly contributing to advancements in precision medicine.
Compared to conventional research models, SHISA3 knockout cell lines offer unique advantages, including higher specificity in gene disruption and better representation of in vivo conditions, which can lead to more reliable and translatable findings. This specificity reduces the likelihood of off-target effects, enhancing the validity of experimental outcomes.
For researchers and clinicians, the value of utilizing SHISA3 Gene Knockout Cell Lines lies in their capacity to unlock new avenues in understanding complex biological systems, ultimately propelling innovations in disease treatment and prevention.
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