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SH3TC2 Knockout Cell Lines

Gene: SH3TC2

Official Full Name: SH3 domain and tetratricopeptide repeats 2provided by HGNC

Gene Summary: This gene encodes a protein with two N-terminal Src homology 3 (SH3) domains and 10 tetratricopeptide repeat (TPR) motifs, and is a member of a small gene family. The gene product has been proposed to be an adapter or docking molecule. Mutations in this gene result in autosomal recessive Charcot-Marie-Tooth disease type 4C, a childhood-onset neurodegenerative disease characterized by demyelination of motor and sensory neurons. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20330 SH3TC2 Knockout cell line (HeLa) Human SH3TC2 1:3~1:6 Negative Online Inquiry
KO20331 SH3TC2 Knockout cell line (HCT 116) Human SH3TC2 1:2~1:4 Negative Online Inquiry

Background

SH3TC2 Gene Knockout Cell Lines are meticulously engineered cellular models designed for advanced genetic research, particularly in the study of cell signaling pathways, neuropathies, and disease mechanisms. The SH3TC2 gene is known to play a crucial role in Schwann cell function and peripheral nerve integrity. By creating knockout cell lines that lack functional SH3TC2 expression, researchers can critically assess the implications of its absence on cellular behavior and signaling responses.

These knockout cell lines facilitate the investigation of the molecular mechanisms underlying various pathologies, including hereditary neuropathies, by allowing scientists to study the direct effects of SH3TC2 deficiency on cell proliferation, differentiation, and apoptosis. The precise knockout methodology, often utilizing CRISPR-Cas9 technology, ensures specific and reproducible gene disruption, enabling clear insights into gene function.

In addition to their significance in basic research, SH3TC2 Gene Knockout Cell Lines hold substantial potential in clinical settings, particularly for drug discovery and testing, where understanding the genetic basis of peripheral neuropathy can lead to the development of targeted therapies. Compared to standard cell lines, these specialized models provide a unique advantage by mimicking human disease conditions more closely, thus enhancing translational research outcomes.

The value of SH3TC2 Gene Knockout Cell Lines lies in their ability to empower researchers and clinicians with precise tools to unravel complex genetic interactions and disease mechanisms. With our company’s dedicated expertise in genetic engineering and cell line development, we offer high-quality products that stand at the forefront of scientific advancement, ensuring that our clients can make groundbreaking discoveries in their respective fields.

Please note that all services are for research use only. Not intended for any clinical use.

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