Gene: SH3PXD2B
Official Full Name: SH3 and PX domains 2Bprovided by HGNC
Gene Summary: This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome (FTHS), and also Borrone Dermato-Cardio-Skeletal (BDCS) syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14161 | SH3PXD2B Knockout cell line (HeLa) | Human | SH3PXD2B | 1:3~1:6 | Negative | Online Inquiry |
KO14162 | SH3PXD2B Knockout cell line (HCT 116) | Human | SH3PXD2B | 1:2~1:4 | Negative | Online Inquiry |
KO14163 | SH3PXD2B Knockout cell line (HEK293) | Human | SH3PXD2B | 1:3~1:6 | Negative | Online Inquiry |
KO14164 | SH3PXD2B Knockout cell line (A549) | Human | SH3PXD2B | 1:3~1:4 | Negative | Online Inquiry |
SH3PXD2B Gene Knockout Cell Lines are specialized cellular models engineered for the precise study of the SH3PXD2B gene's function and its implications in cellular processes. These knockout cell lines are created through targeted genome editing techniques, such as CRISPR/Cas9, allowing for the complete disruption of the SH3PXD2B gene expression. This tool provides researchers with the ability to explore the gene's role in various biological phenomena, including cellular migration, adhesion, and signaling pathways, which are critical in cancer biology and developmental studies.
The SH3PXD2B protein is recognized for its involvement in clathrin-mediated endocytosis, a vital mechanism by which cells internalize molecules and regulate signaling pathways. By utilizing these knockout cell lines, researchers can investigate how the absence of SH3PXD2B alters cellular behavior and influences disease states. The ability to analyze gene function in a controlled environment opens avenues for understanding complex interactions in physiological and pathological contexts, making these cell lines invaluable for both basic and applied research.
One of the notable advantages of the SH3PXD2B Gene Knockout Cell Lines is their specificity and reproducibility. Unlike traditional methods that may rely on pharmacological inhibition, knockout models provide a more straightforward and permanent alteration of gene function, facilitating clearer insights into gene activity and interactions. This specificity also enhances the validity of research findings, making them more translatable to in vivo studies.
For researchers and clinicians looking to elucidate mechanisms of disease or to develop therapeutic strategies, these knockout cell lines serve as a powerful platform. They empower users to innovate and propel their research toward tangible outcomes, while also offering a means to identify potential biomarkers or therapeutic targets associated with SH3PXD2B dysregulation.
Our company prides itself on its commitment to developing high-quality, research-ready biological products that support the advancement of scientific knowledge and clinical practice. By providing robust tools like SH3PXD2B Gene Knockout Cell Lines, we aim to facilitate groundbreaking discoveries and foster collaboration within the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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