Gene: SH3GL2
Official Full Name: SH3 domain containing GRB2 like 2, endophilin A1provided by HGNC
Gene Summary: Enables identical protein binding activity. Involved in negative regulation of blood-brain barrier permeability; negative regulation of gene expression; and negative regulation of protein phosphorylation. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35451 | SH3GL2 Knockout cell line (HeLa) | Human | SH3GL2 | 1:3~1:6 | Negative | Online Inquiry |
KO35452 | SH3GL2 Knockout cell line (HEK293) | Human | SH3GL2 | 1:3~1:6 | Negative | Online Inquiry |
SH3GL2 Gene Knockout Cell Lines are specialized cellular models where the SH3GL2 gene has been precisely disrupted using advanced gene-editing technologies. These cell lines are essential tools for investigating the role of the SH3GL2 gene in various biological processes, particularly in endocytosis and intracellular trafficking, as SH3GL2 encodes a protein that is pivotal for actin organization and membrane dynamics.
The key mechanism underlying the functionality of SH3GL2 knockout cell lines lies in the absence of the SH3GL2 protein, allowing researchers to study the effects of this loss on cellular pathways. By comparing the phenotype and behavior of these knockout cells to their wild-type counterparts, scientists can gain insights into how SH3GL2 influences the regulation of membrane curvature and vesicle formation, particularly in response to extracellular signals. These cellular alterations are crucial for elucidating the gene's involvement in various diseases, including cancer and neurological disorders.
The scientific importance of SH3GL2 Gene Knockout Cell Lines extends to both research and clinical applications. They serve as a powerful platform for drug discovery and therapeutic development, enabling researchers to screen novel compounds targeting diseases related to SH3GL2 dysregulation. Additionally, they are invaluable in the study of genetic interactions and pathways involved in tumorigenesis or neurodegenerative processes.
Compared to alternative gene knockout models, such as transient knockdown systems or conventional knockout mice, SH3GL2 Gene Knockout Cell Lines offer several advantages. They provide a consistent and stable background, ensuring reproducibility in experiments and allowing for more robust data collection. Moreover, their ease of use in high-throughput screening assays makes them particularly attractive for pharmacological research.
For researchers and clinicians focused on understanding the complex interplay of genes in health and disease, SH3GL2 Gene Knockout Cell Lines represent a critical resource that advances knowledge and drives discoveries forward. Our company is proud to leverage cutting-edge gene-editing technologies and deep biological insights to deliver high-quality, reliable biological products that empower your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.