Gene: SETMAR
Official Full Name: SET domain and mariner transposase fusion geneprovided by HGNC
Gene Summary: This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35473 | SETMAR Knockout cell line (HeLa) | Human | SETMAR | 1:3~1:6 | Negative | Online Inquiry |
KO35474 | SETMAR Knockout cell line (HCT 116) | Human | SETMAR | 1:2~1:4 | Negative | Online Inquiry |
KO35475 | SETMAR Knockout cell line (HEK293) | Human | SETMAR | 1:3~1:6 | Negative | Online Inquiry |
KO35476 | SETMAR Knockout cell line (A549) | Human | SETMAR | 1:3~1:4 | Negative | Online Inquiry |
SETMAR Gene Knockout Cell Lines are expertly developed cellular models created to specifically target and silence the SETMAR gene, an important player in genome stability and cellular responses to DNA damage. These cell lines utilize advanced CRISPR-Cas9 technology, allowing for precise genome editing that disrupts the SETMAR gene function, enabling researchers to investigate its role in cellular processes and disease mechanisms.
The primary function of SETMAR Gene Knockout Cell Lines is to facilitate the study of the biological implications of SETMAR protein absence, including its involvement in chromosomal integrity, tumorigenesis, and cellular stress responses. By employing knockout methodologies, researchers can analyze how the absence of SETMAR alters cell behavior, proliferation, and response to genotoxic stress, thus elucidating its potential role in cancer and other diseases.
From a scientific perspective, these cell lines are invaluable in research and clinical applications, enabling the dissection of complex genetic interactions and the evaluation of novel therapeutic approaches. The utility of these models extends to drug discovery and preclinical testing, allowing for the assessment of treatment efficacy and mechanisms of action against SETMAR-related pathologies.
Compared to alternative tools such as antisense oligonucleotides or RNA interference technology, SETMAR Gene Knockout Cell Lines provide a more stable and enduring gene disruption, allowing for longitudinal studies and improved reproducibility. This long-term modification is advantageous in various experimental scenarios, providing confidence in experimental outcomes and enhancing the reliability of conclusions drawn from the data.
For researchers and clinicians, the SETMAR Gene Knockout Cell Lines present a unique opportunity to advance our understanding of fundamental biological processes and disease states. By utilizing these innovative and rigorous models, they can drive discoveries that transform therapeutic strategies and improve patient outcomes.
Our company specializes in cutting-edge genetic models and gene editing technologies, ensuring that our products meet the highest scientific standards. We are committed to empowering researchers with the tools they need to achieve groundbreaking advancements in their fields.
Please note that all services are for research use only. Not intended for any clinical use.
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