Gene: SEMA6D
Official Full Name: semaphorin 6Dprovided by HGNC
Gene Summary: Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14221 | SEMA6D Knockout cell line (HEK293) | Human | SEMA6D | 1:3~1:6 | Negative | Online Inquiry |
SEMA6D Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to disrupt the expression of the SEMA6D gene, a member of the semaphorin family implicated in various biological processes, including neural development, angiogenesis, and immune regulation. These knockout cell lines provide researchers with valuable tools for investigating the physiological and pathological roles of SEMA6D, facilitating a deeper understanding of its mechanisms in cellular signaling pathways.
The primary function of these cell lines revolves around their ability to eliminate SEMA6D gene expression, thereby allowing researchers to study the downstream effects of this perturbation in cellular behavior. By utilizing CRISPR-Cas9 technology, the SEMA6D Gene Knockout Cell Lines ensure precise and effective deletion of the target gene, leading to observable changes in cell migration, proliferation, and differentiation. This can be particularly insightful in contexts such as cancer biology, where aberrant semaphorin signaling has been associated with tumor progression and metastasis.
In a clinical or research setting, understanding the role of SEMA6D through these knockout cell lines can contribute significantly to the development of therapeutic strategies. For instance, by elucidating the pathways influenced by SEMA6D, scientists can identify potential targets for drug development or biomarker discovery, particularly in neurodegenerative diseases or cancer.
One of the standout advantages of the SEMA6D Gene Knockout Cell Lines is their specificity and reliability; the CRISPR-Cas9 mediated gene editing approach offers a high degree of precision compared to traditional gene silencing techniques such as RNA interference, which may lead to off-target effects. Additionally, the adaptability of these cell lines to various culturing conditions and their compatibility with high-throughput screening make them a versatile asset for laboratories focused on genetic research.
For researchers and clinicians alike, the SEMA6D Gene Knockout Cell Lines represent a vital resource for advancing our understanding of semaphorin biology and its implications in health and disease. As leaders in genetic engineering, our company prides itself on providing high-quality biological products tailored to meet the ever-evolving needs of the scientific community, ensuring researchers have access to the tools necessary to make impactful discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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