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SELL Knockout Cell Lines

Gene: SELL

Official Full Name: selectin Lprovided by HGNC

Gene Summary: This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03421 SELL Knockout cell line (HCT 116) Human SELL 1:2~1:4 Negative Online Inquiry

Background

SELL Gene Knockout Cell Lines are a cutting-edge biological product designed for advanced research in gene function and therapeutic development. These cell lines have been meticulously engineered to lack the SELL gene, which encodes for the L-selectin protein involved in leukocyte trafficking and immune response modulation. By facilitating the study of the precise roles and interactions of the SELL gene within various biological contexts, these knockout cell lines serve as an invaluable tool for researchers exploring mechanisms underlying inflammation, cancer metastasis, and autoimmune diseases.

The key functionality of SELL Gene Knockout Cell Lines lies in their ability to provide a focused model for dissecting the biological implications of L-selectin deficiency. They enable researchers to investigate downstream signaling pathways, assess alterations in cellular adhesion properties, and elucidate the impact of SELL gene loss on immune cell behavior. This precise knockout enables comparative analyses with wild-type cells, thereby enhancing the understanding of L-selectin's role in pathophysiological conditions.

From a scientific standpoint, SELL Gene Knockout Cell Lines have significant implications in both basic and applied research settings. They can facilitate drug discovery efforts aimed at targeting L-selectin pathways, developing novel immunotherapies, or identifying biomarkers for disease states. Moreover, these cell lines can be particularly useful in preclinical models to explore therapeutic efficacy and safety.

One of the standout advantages of our SELL Gene Knockout Cell Lines is their rigorous validation and characterization, ensuring reliability and reproducibility in experimental settings. Compared to alternative models, our cell lines provide a fully controlled genetic environment, eliminating off-target effects commonly witnessed with traditional RNA interference methods.

For researchers and clinicians, the value of SELL Gene Knockout Cell Lines extends beyond mere experimentation; they present opportunities to innovate and advance scientific understanding in immunology and related fields. By leveraging these tools, users can expect more accurate and insightful results that pave the way for breakthroughs in treatment strategies.

Our company specializes in providing high-quality biological products and solutions tailored to the needs of the research community, with an unwavering commitment to fostering scientific advancement and innovation. We invite you to explore the potential of our SELL Gene Knockout Cell Lines to enhance your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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