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SEC23IP Knockout Cell Lines

Gene: SEC23IP

Official Full Name: SEC23 interacting proteinprovided by HGNC

Gene Summary: This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31089 SEC23IP Knockout cell line (HeLa) Human SEC23IP 1:3~1:6 Negative Online Inquiry
KO31090 SEC23IP Knockout cell line (HCT 116) Human SEC23IP 1:2~1:4 Negative Online Inquiry
KO31091 SEC23IP Knockout cell line (HEK293) Human SEC23IP 1:3~1:6 Negative Online Inquiry
KO31092 SEC23IP Knockout cell line (A549) Human SEC23IP 1:3~1:4 Negative Online Inquiry

Background

SEC23IP Gene Knockout Cell Lines are specifically engineered cellular models in which the SEC23IP gene has been disrupted through contemporary genome editing techniques, notably CRISPR-Cas9. SEC23IP, or SEC23 Interacting Protein, plays a critical role in the endoplasmic reticulum (ER) to Golgi transport mechanism and is pivotal for maintaining cellular homeostasis. The knockout of this gene allows researchers to dissect the protein's functions and interactions, facilitating the exploration of pathways related to vesicular trafficking and cellular signaling.

The mechanism underlying the utility of SEC23IP knockout cell lines lies in their ability to mimic pathological states by disrupting normal protein function, which can lead to significant insights into various diseases, including neurodegenerative disorders and metabolic syndromes. By studying these cell lines, researchers can identify compensatory pathways and potential therapeutic targets, thereby broadening the understanding of cell biology and disease mechanisms.

The scientific importance of SEC23IP knockout cell lines extends to both fundamental research and clinical applications. They offer a reliable platform for drug discovery, testing the efficacy of new compounds on modified cellular environments. Additionally, these cell lines can serve as valuable tools in the development of gene therapies, paving the way for innovative treatments tailored to specific molecular defects.

Compared to traditional cell lines, the knockout of SEC23IP allows for a precise study of gene function and regulation, minimizing the variabilities associated with off-target effects. This targeted approach enhances the reproducibility of experiments, yielding more reliable data and accelerating the pace of biomedical research.

Researchers, clinicians, and biotechnologists will find exceptional value in SEC23IP Gene Knockout Cell Lines due to their ability to advance our understanding of complex biological processes and diseases. These cell lines represent a significant leap forward in cellular modeling, providing critical insights and innovation at the molecular level.

Our company prides itself on its expertise in providing high-quality biological products and custom cell lines designed to meet the evolving needs of scientific research. Through our commitment to precision and excellence, we empower the scientific community to uncover new horizons in health and disease understanding.

Please note that all services are for research use only. Not intended for any clinical use.

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