Gene: SCYL1
Official Full Name: SCY1 like pseudokinase 1provided by HGNC
Gene Summary: This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14268 | SCYL1 Knockout cell line (HeLa) | Human | SCYL1 | 1:3~1:6 | Negative | Online Inquiry |
KO14269 | SCYL1 Knockout cell line (HCT 116) | Human | SCYL1 | 1:2~1:4 | Negative | Online Inquiry |
KO14270 | SCYL1 Knockout cell line (HEK293) | Human | SCYL1 | 1:3~1:6 | Negative | Online Inquiry |
KO14271 | SCYL1 Knockout cell line (A549) | Human | SCYL1 | 1:3~1:4 | Negative | Online Inquiry |
SCYL1 Gene Knockout Cell Lines represent a cutting-edge tool for investigating the biological roles of the SCYL1 gene, which encodes a protein involved in intracellular trafficking and endosomal functions. This product entails engineered cell lines in which the SCYL1 gene has been disrupted, allowing researchers to study the consequences of its absence on cellular functions and signaling pathways. By utilizing CRISPR/Cas9 technology, these knockout cell lines provide a precise and efficient means of observing phenotypic changes attributed to SCYL1 loss-of-function.
The primary mechanism by which SCYL1 influences cellular processes involves its participation in the regulation of endosomal dynamics, notably in the recycling of membrane proteins and vesicle transport. By employing SCYL1 knockout cell lines, researchers can elucidate the gene's role in cellular homeostasis, membrane trafficking, and potential linkages to diseases such as cancer or neurodegenerative disorders. These applications are crucial for elucidating the pathophysiology of various conditions and for the development of targeted therapeutics.
One of the unique advantages of SCYL1 Gene Knockout Cell Lines is their robustness in experimental settings that scrutinize the molecular underpinnings of cellular transport mechanisms. Unlike traditional approaches that may involve transient transfection methodologies, the stable knockout ensures long-term expression and observation of phenotypic traits without variability introduced by transient expression vectors. Additionally, these cell lines provide a system for high-throughput screening of drugs or compounds that may modulate SCYL1-related pathways, advancing drug discovery efforts.
For researchers and clinicians focusing on cellular trafficking, signal transduction, or disease modeling, the SCYL1 Gene Knockout Cell Lines offer an invaluable resource. The specificity and reliability of these models empower users to draw meaningful conclusions about the efficacy of therapeutic interventions targeted at SCYL1-related processes. At [Your Company Name], we pride ourselves on our commitment to advancing scientific research through state-of-the-art products like these, developed by our team of experts dedicated to providing high-quality biological tools for the global research community.
Please note that all services are for research use only. Not intended for any clinical use.
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