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SAMD11 Knockout Cell Lines

Gene: SAMD11

Official Full Name: sterile alpha motif domain containing 11provided by HGNC

Gene Summary: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and protein domain specific binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and retinal rod cell development. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be part of PRC1 complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO23421 SAMD11 Knockout cell line (HeLa) Human SAMD11 1:3~1:6 Negative Online Inquiry
KO23422 SAMD11 Knockout cell line (HEK293) Human SAMD11 1:3~1:6 Negative Online Inquiry
KO23423 SAMD11 Knockout cell line (A549) Human SAMD11 1:3~1:4 Negative Online Inquiry

Background

SAMD11 Gene Knockout Cell Lines are meticulously engineered cellular models designed to facilitate the study of the SAMD11 gene, known for its roles in cellular processes such as immune response and cell signaling. These cell lines feature targeted knockout of the SAMD11 gene, leading to the complete absence of its expression, thereby enabling researchers to explore the gene's functional implications and its contribution to various biological pathways.

The core mechanism underlying the SAMD11 knockout cells is the CRISPR-Cas9 genome editing technology, which allows for precise alterations in the DNA sequence, ensuring the elimination of the SAMD11 gene without affecting adjacent genomic regions. This knockout model enables comprehensive analysis of the downstream effects on cellular phenotypes, including proliferation, apoptosis, and innate immune responses. By using these cell lines, researchers can uncover the role of SAMD11 in pathophysiological conditions, including autoimmune diseases and cancer.

The scientific importance of SAMD11 Gene Knockout Cell Lines is underscored by their applicability in both basic research and translational studies. In research settings, they provide a robust framework for investigating gene function and interactions within complex biological systems. In clinical contexts, this product aids in the development of targeted therapies, potentially leading to novel treatments for diseases influenced by SAMD11 dysregulation.

Compared to alternative cellular models, the SAMD11 Gene Knockout Cell Lines offer heightened specificity and reliability. Traditional knockdown approaches using siRNA or shRNA may not achieve consistent gene suppression, whereas knockout lines provide a stable and permanent solution for gene function analysis. This permanence fosters reproducibility in experiments, making findings more reliable.

For researchers and clinicians seeking to delve into the functionalities of SAMD11, our product presents a unique opportunity to provide insights critical for advancing knowledge in cellular mechanisms and therapeutic developments. Our company specializes in providing high-quality biological products, ensuring that our customers receive trusted and validated tools for their research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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