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SALL3 Knockout Cell Lines

Gene: SALL3

Official Full Name: spalt like transcription factor 3provided by HGNC

Gene Summary: This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis. [provided by RefSeq, Oct 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27773 SALL3 Knockout cell line (HEK293) Human SALL3 1:3~1:6 Negative Online Inquiry

Background

SALL3 Gene Knockout Cell Lines are genetically engineered cells that have been specifically designed to lack the SALL3 gene, a critical regulatory gene involved in various developmental processes and cellular functions. These cell lines are invaluable tools for researchers exploring gene function, disease mechanisms, and potential therapeutic targets. By providing a system to study the loss-of-function effects of the SALL3 gene, researchers can better understand its role in cellular proliferation, differentiation, and apoptosis.

The key functions of SALL3 are centered around its role as a transcription factor, where it influences the expression of other genes involved in developmental pathways. The knockout of this gene allows for the examination of downstream effects and the identification of pathways that may be disrupted in various conditions, including certain cancers and congenital disorders. In this way, SALL3 Gene Knockout Cell Lines serve as an essential platform for elucidating molecular and genetic interactions within the cellular environment.

Scientifically, these cell lines possess significant importance in both research and clinical settings. In research, they provide a means to validate hypotheses concerning gene function and assess the consequences of gene deletion in a controlled environment. Clinically, insights gained from such models can lead to the discovery of novel biomarkers or therapeutic targets for diseases associated with aberrant SALL3 activity.

What sets SALL3 Gene Knockout Cell Lines apart from other genetic cell models is their robustness, superior genetic stability, and the specific targeting of the SALL3 gene, which is often overlooked in conventional cell lines. This specificity allows for more nuanced experimental designs and data interpretation, presenting a clear advantage for researchers focused on precise genetic pathways.

Given the increasing demand for precise genetic models in contemporary biomedical research, SALL3 Gene Knockout Cell Lines represent a critical asset for researchers and clinicians alike. With a strong focus on innovation and quality, our company offers these cutting-edge cell lines, employing advanced gene editing techniques to ensure the highest standards of genetic manipulation. Researchers can rely on our expertise to support their investigative endeavors and advance their understanding of complex biological systems.

Please note that all services are for research use only. Not intended for any clinical use.

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