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S100A6 Knockout Cell Lines

Gene: S100A6

Official Full Name: S100 calcium binding protein A6provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35545 S100A6 Knockout cell line (HeLa) Human S100A6 1:3~1:6 Negative Online Inquiry
KO35546 S100A6 Knockout cell line (HCT 116) Human S100A6 1:2~1:4 Negative Online Inquiry
KO35547 S100A6 Knockout cell line (HEK293) Human S100A6 1:3~1:6 Negative Online Inquiry
KO35548 S100A6 Knockout cell line (A549) Human S100A6 1:3~1:4 Negative Online Inquiry

Background

S100A6 Gene Knockout Cell Lines are genetically modified cell lines that have been specifically engineered to lack the expression of the S100A6 gene, part of the S100 family of calcium-binding proteins. These cell lines serve as critical tools for researchers investigating the roles of S100A6 in cellular processes, such as proliferation, differentiation, and stress responses. By removing S100A6, scientists can explore its functional contributions, gaining insights into various pathophysiological conditions, including cancer, inflammation, and neurodegenerative diseases.

The primary mechanism of action involves the disruption of the S100A6 gene using advanced genome editing techniques such as CRISPR-Cas9. This precise alteration allows for the study of the resultant phenotypic changes in cell behavior and signaling pathways. Researchers can assess how the absence of S100A6 influences molecular interactions, potentially uncovering novel regulatory networks involved in disease states.

The scientific importance of S100A6 knockout cell lines cannot be overstated; they represent an invaluable resource in understanding the molecular underpinnings of various diseases and developing targeted therapies. These cell lines have broad applications in fields such as cancer biology, immunology, and neurology, facilitating breakthroughs in disease modeling and drug discovery.

What sets our S100A6 Gene Knockout Cell Lines apart from other available products is the rigor of our validation processes and the quality assurance protocols we employ, ensuring high specificity and consistent performance. Our cell lines come extensively characterized, allowing researchers to confidently interpret their experimental results without concerns about off-target effects or genetic stability.

For researchers and clinicians looking to deepen their understanding of S100A6's role in health and disease, our product offers significant value. The ability to observe the direct effects of S100A6 knockout on cellular behavior enhances the potential for innovative discoveries and therapeutic advancements.

As a company committed to excellence in biological research tools, we leverage cutting-edge technology and extensive experience to provide high-quality gene knockout products that empower scientists and advance biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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