Gene: S100A2
Official Full Name: S100 calcium binding protein A2provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35538 | S100A2 Knockout cell line (HeLa) | Human | S100A2 | 1:3~1:6 | Negative | Online Inquiry |
KO35539 | S100A2 Knockout cell line (HCT 116) | Human | S100A2 | 1:2~1:4 | Negative | Online Inquiry |
KO35540 | S100A2 Knockout cell line (HEK293) | Human | S100A2 | 1:3~1:6 | Negative | Online Inquiry |
KO35541 | S100A2 Knockout cell line (A549) | Human | S100A2 | 1:3~1:4 | Negative | Online Inquiry |
S100A2 Gene Knockout Cell Lines are engineered cellular models specifically designed to study the biological and pathological roles of the S100A2 gene, which encodes a member of the S100 family of calcium-binding proteins. These cell lines have undergone precise gene editing techniques, such as CRISPR-Cas9, to effectively disrupt the expression of S100A2, enabling researchers to investigate the gene’s contribution to various cellular processes, such as proliferation, differentiation, and apoptosis.
The primary function of S100A2 is to regulate cellular responses to calcium levels, and it plays a pivotal role in cellular signaling pathways associated with inflammation, cancer progression, and the response to tissue injury. By utilizing these knockout cell lines, scientists can elucidate the signaling pathways and mechanisms that are upregulated or downregulated in the absence of S100A2, facilitating a deeper understanding of diseases such as breast cancer and other malignancies where S100A2 is implicated.
In the context of research and clinical applications, S100A2 Gene Knockout Cell Lines provide crucial insights into tumor microenvironments, allowing for the development of targeted therapies and potency assays. These cell lines serve as essential tools for drug discovery and validation of potential therapeutic targets, enhancing the translational potential of research findings into clinical applications.
When compared to traditional models, the S100A2 Gene Knockout Cell Lines offer unparalleled specificity in studying the role of the S100A2 protein without compensatory effects from the wild-type gene. This enables investigators to achieve more accurate and reproducible experimental outcomes, significantly improving the reliability of results.
For researchers and clinicians aiming to advance their understanding of S100A2-related pathways or developing novel therapeutic strategies, our S100A2 Gene Knockout Cell Lines represent an invaluable resource. Our company's commitment to precision and excellence in the development of biological products ensures that our offerings are rigorously validated and tailored to meet the highest scientific standards, empowering advancements in molecular biology and translational medicine.
Please note that all services are for research use only. Not intended for any clinical use.
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